Results 231 to 240 of about 523,125 (295)

A Modular and Programmable Cas13d Platform for RNA Single Nucleotide Variant Detection

Advanced Science, EarlyView.
A scenario‐guided Cas13d platform enables configurable single nucleotide variant ribonucleic acid diagnostics through rule‐based guide design and ribonucleic acid binding domain engineering, supporting amplification‐free ultrasensitive detection and amplification‐coupled robust detection for accurate mutation classification in clinical tumor specimens.
Zeyu Wang, Jiahao Li, Zhuying Yue, Beixuan He, Wenhua Zhang, Zhen Fang, Qing Xia, Yingbin Liu, Yanjing Li   +8 more
wiley   +1 more source

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Clinicians' Personal Delivery Preference and Decision-Making for Cesarean Delivery: A Survey of Obstetricians and Midwives. [PDF]

Risk Manag Healthc Policy
Aldardeir NF, Sulaimani MA, Bahowarth SY, Almanasif M, Alghamdi YS, Aseeri SS, Alsulymani B, Heggi R, Hasanain R, Alyazidi A.   +9 more
europepmc   +1 more source

Epigenetic Silencing of RFX7 Defines a Transcriptional Axis Linking Lactate Metabolism to Immune Checkpoint Therapy in Glioblastoma

Advanced Science, EarlyView.
Glioblastoma (GBM) exhibits RFX7 silencing via promoter hypermethylation, which downregulates PIK3IP1 to activate PI3K/AKT signaling, increase lactate accumulation, and enhance histone H4K12 lactylation. This lactylation upregulates PD‐L1/CSF1 expression and drives the immunosuppressive microenvironment formation.
Liying Han, Jinpeng Zhou, Gang Zhu, Fan Chen, Leiyang Li, Wenxing Cui, Fang Sun, Tian Feng, Yue Zhang, Qiang Wang, Shuoyao Ma, Chengxuan Guo, Ziwen Zhang, Kai Wang, Jiahui Wang, Liangbo Wang, Wencong Li, Chenyi Yuan, Haixiao Liu, Liang Wang, Yan Qu   +20 more
wiley   +1 more source

The detection of episodic memory in others biases social choice. [PDF]

Proc Natl Acad Sci U S A
Ciaramelli E, Waisman A, Stendardi D, Moscovitch M.   +3 more
europepmc   +1 more source

The self-interest of adolescents overrules cooperation in social dilemmas. [PDF]

Elife
Wu X, Fu H, Aydogan G, Feng C, Qin S, Zeng Y, Liu C.   +6 more
europepmc   +1 more source

Novel behavioral tasks for the measurement of social motivation in mice: a comparison across strains. [PDF]

Front Behav Neurosci
Wells C, Huddleston KP, Brown S, Razzaq F, Chick D, Rogers TD.   +5 more
europepmc   +1 more source

Task-shifting through community health workers: factors influencing access and utilization of modern family planning methods in Ziniaré, Burkina Faso. [PDF]

Front Reprod Health
Koinda F, Gitau T, Zoungrana W, Yegon E, Mwita N, Zongo A, Sawadogo L, Koimur A, Nyabonyi C, Omondi Omollo R, Kyalo Njoroge J, Ky Yolland A, Tassembedo M.   +12 more
europepmc   +1 more source

Quality of intrapartum care assessed by women with fear of birth who received care in a midwifery continuity model in a rural area of Sweden- a longitudinal cohort study. [PDF]

BMC Pregnancy Childbirth
Hildingsson I, Nääs KL, Wiklund I, Johansson M.   +3 more
europepmc   +1 more source

The prairie vole gut-brain-microbiota-axis: a narrative review. [PDF]

Gut Microbiome (Camb)
Nuccio DA, Grippo A, Singh P.
europepmc   +1 more source