Results 111 to 120 of about 214,292 (293)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
New Hampshire civic health index [PDF]
, 2009 The Carsey Institute is participating in a study to examine America\u27s civic health. Led by the Conference on Citizenship (NCoC), America\u27s Civic Health Index is an annual study that measures a wide variety of civic indicators, such as community ...
Dillon, Michele, Rogers, Shannon H.
core +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Selected Scientific Papers: Journal of Civil Engineering, 2014 The present paper uses the developed model of the influence of partnering relations on the time, cost, quality and safety of implementation of construction projects.
Radziszewska-Zielina Elżbieta +1 more
doaj +1 more source
Strategic technology alliances by European firms since 1980: questioning integration? [PDF]
This paper evaluates the extent to which private, non-subsidised cooperative agreements in R&D by EU firms has evolved, paying particular attention to the extent to which economic integration may have influenced intra-EU activity relative to extra-EU ...
Narula,Rajneesh
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Leadership in construction partnering projects [PDF]
In recent years there has been a growing interest in the use of partnering in construction. Central to any successful partnering arrangement is the change in cultural and behavioural characteristics towards mutual trust and understanding. Leadership is
Amaratunga, Dilanthi +2 more
core
Engaging Consumers to Improve Ambulatory Care [PDF]
, 2012 Presents lessons learned from the experiences of five Aligning Forces for Quality communities in partnering with patients, families, and caregivers to improve ambulatory care, including integrating patient engagement into existing improvement ...
core
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source