Results 81 to 90 of about 1,122,829 (306)

Effective workplaces – bridging the gap between architectural research and design practice. [PDF]

open access: yes, 2007
Architectural researchers and design practitioners mostly segregate in distinct communities with hardly any overlap, collaboration or exchange of ideas.
Budgen, A   +4 more
core  

Morale among general practitioners:qualitative study exploring relations between partnership arrangements, personal style, and workload [PDF]

open access: yes, 2002
OBJECTIVES: To explore general practitioners' experiences of wellbeing and distress at work, to identify their perceptions of the causes of and solutions to distress, and to draw out implications for improving morale in general practice.
Gerry, Marian   +5 more
core   +2 more sources

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Efficient partnership dissolution under buy-sell clauses [PDF]

open access: yes, 2006
When a partnership comes to an end, partners have to determine the terms of the dissolution. A well known way to do so is by enforcing a buy-sell clause.
Frutos, María Ángeles de   +1 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Toward Advanced Nursing Practice along with People-Centered Care Partnership Model for Sustainable Universal Health Coverage and Universal Access to Health

open access: yesRevista Latino-Americana de Enfermagem
Objective: this study developed a people-centered care (PCC) partnership model for the aging society to address the challenges of social changes affecting people’s health and the new role of advanced practice nurses to sustain universal health coverage.
Tomoko Kamei   +8 more
doaj   +1 more source

Exploring the Perceptions of Young People in Care and Care Leavers of the Health needs [PDF]

open access: yes, 2003
This paper presents findings from a research study into the health needs and concerns of young people in care and leaving care (aged 14 to 24 years) carried out in Glasgow during 2001 (Scottish Health Feedback 2001). The study was commissioned by Glasgow
McCluskey, Steven, Ridley, Julie
core  

The OneTogether collaborative approach to reduce the risk of surgical site infection: identifying the challenges to assuring best practice [PDF]

open access: yes, 2015
Background: Surgical site infections (SSI) account for 16% of healthcare associated infections, and are associated with considerable morbidity, mortality and increased costs of care.
Gallagher, Rose   +4 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Digital Multidomain Lifestyle Intervention for Community-Dwelling Older Adults: A Mixed Methods Evaluation

open access: yesInternational Journal of Public Health
ObjectivesAs life expectancy rises at a faster rate than healthy life expectancy, there is a global need for scalable and cost-effective interventions that enhance the health-related quality of life of older adults.
Renato Mattli   +11 more
doaj   +1 more source

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