Results 81 to 90 of about 1,130,579 (304)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Efficient partnership dissolution under buy-sell clauses [PDF]

, 2006
When a partnership comes to an end, partners have to determine the terms of the dissolution. A well known way to do so is by enforcing a buy-sell clause.
Frutos, María Ángeles de, Kittsteiner, Thomas   +1 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Toward Advanced Nursing Practice along with People-Centered Care Partnership Model for Sustainable Universal Health Coverage and Universal Access to Health

Revista Latino-Americana de Enfermagem
Objective: this study developed a people-centered care (PCC) partnership model for the aging society to address the challenges of social changes affecting people’s health and the new role of advanced practice nurses to sustain universal health coverage.
Tomoko Kamei, Keiko Takahashi, Junko Omori, Naoko Arimori, Michiko Hishinuma, Kiyomi Asahara, Yoko Shimpuku, Kumiko Ohashi, Junko Tashiro   +8 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Partnership law for the new millennium [PDF]

, 2001
Paper outlining the history of partnership law in the United Kingdom and suggested proposals from the Law Commission for England and Wales and the Scottish Law Commission for reform to problem areas such as: the firm as equity, unnecessary closure of ...
Henning, Johan J.
core  

Plugging a hole and lightening the burden: A process evaluation of a practice education team [PDF]

, 2007
Aim: To investigate the perceptions of clinical and senior managers about the role of Practice Educators employed in one acute hospital in the UK. Background: Producing nurses who are fit for practice, purpose and academic award is a key issue for ...
An Bord Altranais, Andrews M, Browne N, Clarke A, Clifford C, Day C, Department of Health, Department of Health &, Department of Health and Children, Dorset and South Wiltshire Education Purchasing Consortium, Duffy K, English National Board, Higginbottom G, Hollingworth S, Humphreys A, Hunt JA, Ioannides AP, Jowett R, Kenny G, Lathlean J, Luker K, Mallik M, Martin L, Miles MB, Nursing and Midwifery Council, Ovretveit J, Quality Assurance Agency for Higher Education, Quality Assurance Agency for Higher Education, Redwood S, Reeves S, Robertson CM, Rowan P, Simons H, Smith M, Trudigan J, United Kingdom Central Council, Wenger E   +36 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Foresight, Partnerships, and Cross Sector Collective Impact: Strategies to Build A Partnership World

Interdisciplinary Journal of Partnership Studies
This article discusses the value of connecting foresight leadership with partnership practice to achieve cross-sector collective impacts. The dimensions of future consciousness and foresight literacy are described.
Daniel Pesut
doaj   +1 more source

Evaluation of the generations together programme: learning so far. Research report DFE-RR082 [PDF]

, 2011
"This report presents the findings from the evaluation of the Generations Together Demonstrator programme. This study was undertaken by York Consulting LLP on behalf of the then Department for Children, Schools and Families (DCSF); this is now the ...
Crowther, Kathryn, Merrill, Kerry
core