Results 111 to 120 of about 1,543,646 (293)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Transforming partnerships through transboundary research

BMJ Global Health
Research partnerships are a key entry point for addressing the asymmetries that pervade global health. However, highly competitive and fast-paced science limits the kind of innovation and transformative change needed to reduce the imbalances that undermine the independence and academic freedom of research partners.
Alfredo Mayor, Lemu Golassa, Hamtandi Magloire Natama, Alberto L Garcia-Basteiro, Tacilta Nhampossa   +4 more
openaire   +3 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Shelter from the Storm: Assessing the Economic Impacts of the Affordable Housing Bond Act of 2016 (SB 879 Beall) [PDF]

, 2016
In collaboration with the California Housing Partnership, the research department of the Northern California Carpenters Regional Council (NCCRC) analyzed the economic impacts of the Affordable Housing Bond Act of 2016 (SB 879 Beall).

core  

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Support for young people who are distressed by hearing voices: protocol for an uncontrolled feasibility evaluation of a psychological intervention package delivered within secondary schools (the ECHOES study)

Pilot and Feasibility Studies
Background Hearing voices is a common experience for young people and can cause significant distress. There are no evidence-based psychological interventions for distressing voices in young people, although a focus on coping strategies has been suggested
Mark Hayward, Mary John, Sarah Parry, Anna-Marie Bibby-Jones, Faith Orchard, Fiona Malpass, Clare Dixon, Akira Naito   +7 more
doaj   +1 more source

How to ensure partnerships go wrong [PDF]

, 2011
This paper is based upon recent academic research on partnership working in a variety of contexts and personal experience of strategic partnerships in the UK.
Peters, Geoff
core  

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

ANALISA PERAN AKTIF INDONESIA DALAM PEMBENTUKAN REGIONAL COMPREHENSIVE ECONOMIC PARTNERSHIP (RCEP) [PDF]

This research was initiated by Indonesia's initiation in forming the Regional Comprehensive Economic Partnership (RCEP) in 2011, when Indonesia served as the chair of ASEAN.
Hidayah, Wahyu Nikmatul
core  

Intermediate Role of the Criterion of Focus on the Students Benefiting in the Relationship between Adopting the Criterion of Partnership and Resources and Achieving Community Satisfaction in the Palestinian Universities [PDF]

, 2019
The study aimed at identifying the intermediate role of the criterion of emphasis on students and beneficiaries in the relationship between adopting the criterion of partnership and resources and achieving the satisfaction of the society.
Abu-Naser, Samy S., Al Shobaki, Mazen J., FarajAllah, Ahmed M. A., Talla, Suliman A. El   +3 more
core   +2 more sources