Results 111 to 120 of about 416,239 (311)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Support for young people who are distressed by hearing voices: protocol for an uncontrolled feasibility evaluation of a psychological intervention package delivered within secondary schools (the ECHOES study)

Pilot and Feasibility Studies
Background Hearing voices is a common experience for young people and can cause significant distress. There are no evidence-based psychological interventions for distressing voices in young people, although a focus on coping strategies has been suggested
Mark Hayward, Mary John, Sarah Parry, Anna-Marie Bibby-Jones, Faith Orchard, Fiona Malpass, Clare Dixon, Akira Naito   +7 more
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Research partnership inside & outside the curriculum: Opportunities, benefits, & challenges

Drawing on the experiences of two undergraduate students and an academic staff member based in the discipline of geography, this paper will explore the opportunities for student-student and student-staff partnership in research before progressing to ...
Hill, Jennifer, West, Harry, Jenkins, Rhiannon   +2 more
core  

Programme Partnership Arrangement Evaluation 2014: A primary research feedback report

, 2015
The UK's Department for International Development (DFID) is one of Oxfam's most strategically important partners. The Programme Partnership Arrangement (PPA) is a major element of Oxfam's relationship with DFID, providing valuable opportunities for ...

core  

Mind the gap: National and local partnership in the Irish public sector

, 2010
This article uses case study data from a major Irish city council to investigate and explain public sector worker attitudes towards social partnership at local and national level.
Michael Doherty, Roland Erne, Doherty, Michael, Erne, Roland   +3 more
core   +1 more source

The researcher librarian partnership: building a culture of research

, 2014
Increasingly, the library and information science (LIS) practitioner is being challenged to incorporate research into the context of their professional work.
Haidn, Insa, Weech, Terry, Seadle, Michael, Partridge, Helen, Silipigni Connaway, Lynn   +4 more
core   +2 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Partnership for Coastal Watersheds Steering Committee: Phase 2 Strategy

Partnership for Coastal Watersheds (PCW) Phase 2 projects are aligned with the following three objectives to be pursued in parallel: Coos Estuary Inventory Project, Coos Estuary Monitoring Tools, and Phase 1 PCW Action Plan Implementation, Partnership ...
Partnership for Coastal Watersheds
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