Results 141 to 150 of about 416,239 (311)

Civil partnership five years on

, 2011
The Civil Partnership Act 2004, which came into force in December 2005 allowing same-sex couples in the UK to register their relationship for the first time, celebrated its fifth anniversary in December 2010.
Ross, Helen, Gask, Karen, Berrington, Ann   +2 more
core   +1 more source

Understanding implementation of findings from trial method research: a mixed methods study applying implementation frameworks and behaviour change models

Trials
Background Trial method research produces recommendations on how to best conduct trials. However, findings are not routinely implemented into practice.
Taylor Coffey, Paula R. Williamson, Katie Gillies, on behalf of the Trials Methodology Research Partnership Working Groups   +3 more
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

An evaluation of partnership in the development of strategic health policy [PDF]

This PhD analyses strategic health partnerships, focusing on Health Improvement Programmes (HImPs) and Health Action Zones (HAZs). It is a case study of four English health districts, based on 81 semi-structured interviews, and on partnership documents ...
Elston, J
core   +1 more source

The Canadian Frailty Priority Setting Partnership: Research Priorities for Older Adults Living with Frailty. [PDF]

Can Geriatr J, 2019
Bethell J, Puts MTE, Sattar S, Andrew MK, Choate AS, Clarke B, Cowan K, DeAngelis C, Elliott J, Fitch MI, Frank C, Hominick K, Keatings M, McElhaney JE, McKay SM, Pitters E, Ploeg J, Sidani S, McGilton KS.   +18 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Health partnership research and the assessment of effectiveness. [PDF]

Global Health, 2016
Ritman D.
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

Partnership in Practice [PDF]

This paper examines human resource management practices adopted in a group of eight case study firms and their tendencies towards versus away from partnership.
Maria Hudson, Suzanne Konzelmann, Frank Wilkinson   +2 more
core