Results 41 to 50 of about 581,352 (313)

The Role of “Adult‐Onset” Cancer Predisposition Genes in Pediatric Cancer: A Comprehensive Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Current literature estimates that 10% of pediatric cancers are caused by pathogenic or likely pathogenic (P/LP) germline variants in cancer predisposition genes (CPGs). Variants in CPGs thought to increase cancer risk exclusively during adulthood are referred to as “adult‐onset” CPGs (aoCPGs).
Maria Rozo, Miriam A. Bornhorst, Angela J. Waanders, Sara Zarnegar‐Lumley, Ashwin Lakshman Koppayi, Lucy A. Godley   +5 more
wiley   +1 more source

Technical feasibility and uptake of tailored mobile health support for people with HIV in Lesotho

BMC Digital Health
Background Mobile health (mHealth) interventions may improve HIV care in the context of healthcare professional shortages. Here, we evaluate the performance of four mHealth components implemented during the Viral Load Triggered ART Care in Lesotho (VITAL)
Malebanye D. Lerotholi, Mathebe Kopo, Mpho Kao, Lipontso Motaboli, Moleboheng Mokebe, Ntoiseng Chejane, Makobefo Chakela, Bienvenu L. Nsakala, Blaise Lukau, Irene Ayakaka, Morongoe Nyakane, Tapiwa Tarumbiswa, Adrienne E. Shapiro, Mirko S. Winkler, Niklaus D. Labhardt, Nadine Tschumi   +15 more
doaj   +1 more source

Study protocol for a cluster-randomized trial of a bundle of implementation support strategies to improve the fidelity of implementation of schoolwide Positive Behavioral Interventions and Supports in rural schools

Contemporary Clinical Trials Communications, 2022
Background: Improving the implementation of evidence-based interventions is important for population-level impacts. Positive Behavioral Interventions and Supports (PBIS) is effective for improving school climate and students’ behavioral outcomes, but ...
Lindsey Turner, Hannah G. Calvert, Christopher M. Fleming, Teri Lewis, Carl Siebert, Nate Anderson, Tate Castleton, Ashley Havlicak, Michaela McQuilkin   +8 more
doaj   +1 more source

Health Literacy, Self‐Efficacy and Knowledge of Sickle Cell Disease Among Caregivers

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a hereditary blood disorder in which abnormal haemoglobin leads to severe anaemia, painful crises and organ failure. Caregivers’ health literacy (HL) – their ability to assess, understand and apply information, and interact with healthcare professionals – is crucial for managing children with SCD, yet ...
Melanie Bruinooge, Maite E. Houwing, Rowena L. Grohssteiner, Ferdows Atiq, Sonja A. M. C. Teuben, Mirjam P. Fransen, Marjon H. Cnossen   +6 more
wiley   +1 more source

Cross-Sector Partnerships for Systemic Change: Systematized Literature Review and Agenda for Further Research

Journal of Business Ethics, 2018
The literature on cross-sector partnerships has increasingly focused attention on broader systemic or system-level change. However, research to date has been partial and fragmented, and the very idea of systemic change remains conceptually underdeveloped.
Amelia Clarke, A. Crane
semanticscholar   +1 more source

Measurement Approaches to Partnership Success: Theory and Methods for Measuring Success in Long-Standing CBPR Partnerships

Progress in Community Health Partnerships Research Education and Action, 2020
:Background: Numerous conceptual frameworks have been developed to understand how community-based participatory research (CBPR) partnerships function, and multiple measurement approaches have been designed to evaluate them. However, most measures are not
B. Israel, L. Lachance, Chris M. Coombe, S. Lee, Megan Jensen, Eliza Wilson-Powers, G. Mentz, Michael Muhammad, Z. Rowe, Angela G. Reyes, Barbara L. Brush   +10 more
semanticscholar   +1 more source

Early Impact of Childhood Opportunity on Neurocognitive Outcomes in Sickle Cell Disease

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neurocognitive impairment is a well‐recognized complication of sickle cell disease (SCD) that begins early in childhood and persists across development. While cerebrovascular injury contributes substantially to risk, neurocognitive deficits are also observed in children without overt or silent cerebral infarctions, suggesting ...
Julia E. LaMotte, Hannah Koch, Olivia A. Coughlin, Jillian R. Bouck, Allie Carter, Seethal A. Jacob   +5 more
wiley   +1 more source

Use of real-world evidence data to evaluate the comparative effectiveness of second-line type 2 diabetes medications on chronic kidney disease

Journal of Clinical & Translational Endocrinology, 2022
Chronic kidney disease (CKD) is a common complication of type 2 diabetes mellitus (T2DM). Approximately-one-third of patients with T2DM also have CKD.
Yu Deng, Farhad Ghamsari, Alice Lu, Jingzhi Yu, Lihui Zhao, Abel N. Kho   +5 more
doaj   +1 more source

Psychosocial Functioning After Pediatric Bone Sarcoma: Generic and Survivor‐Specific Outcomes in Adolescent and Young Adult Patients

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric bone sarcoma patients and survivors may experience psychosocial challenges related to childhood cancer after their intensive, body‐altering treatment. This cross‐sectional study aimed to evaluate generic and survivor‐specific psychosocial outcomes in a national cohort of pediatric bone sarcoma patients and survivors, and ...
Hinke van der Hoek, Heleen Maurice‐Stam, Laura R. Beek, Jennifer van Dijk, Marjolein E. M. Langemeijer, Relinde W. Slooff‐Lentink, Alied M. van der Aa‐van Delden, Anne Westerweel, Marloes van Gorp, Hendrik W. B. Schreuder, Lianne M. Haveman, W. Peter Bekkering, Leonie G. Tigelaar, Johannes H. M. Merks, Martha A. Grootenhuis   +14 more
wiley   +1 more source

“Research Jam”: Engaging patients and other stakeholders through human-centered design to improve translational research

Journal of Clinical and Translational Science, 2023
Effective stakeholder engagement increases research relevance and utility. Though published principles of community-based participatory research and patient-centered outcomes research offer guidance, few resources offer effective techniques to engage ...
Sarah E. Wiehe, Courtney M. Moore, Dustin O. Lynch, Gina Claxton, Nerissa S. Bauer, Helen Sanematsu   +5 more
doaj   +1 more source