Results 71 to 80 of about 74,123 (248)
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
‘ARS MAIOR’, DONATUS: LINGUISTIC ANALYSIS CRITERIA
Gragoatá, 2016 This article aims at analyzing the grammatical approach given to the parts of speech (partes orationis), by Donatus in his Ars maior (c. IV AD). We intend to evaluate which criteria are used to define, specify and illustrate the parts of speech.
Fábio da Silva Fortes +1 more
doaj
Linguistic Typology at the CrossroadsThis paper presents a corpus-based study of lexemes denoting sounds in Umóⁿhoⁿ (oma), a Siouan language of North America. I take as a starting point a list of sound-denoting verbal roots (in short: “sound roots”), presented as onomatopoeia in a paper by ...
Julie Marsault
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
To the Centralized Testing step by step: The Russian language Activity Book. Part 3
Филологический класс, 2012 The article features a version of Russian workbook for pre-school children devoted to the topic «Structural Parts of Speech». The diverse approach suggested by the authors enables one to grasp the difference between various parts of speech in practice ...
doaj
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source
SPEECH CULTURE OF RUSSIAN LANGUAGE AND MODERN THEORY OF PARTS OF SPEECH STATE
Неофилология, 2016 The part of speech system and speech culture of Russian language speaker is considered. Basing on the example of the “article” «ааа…» which is widely used both at the beginning of utterance and in its parts and parasitic speech content hidden swearing: «
Vladimir Geogrievich Rudelev
doaj