Results 41 to 50 of about 71,003 (250)

A case study showing the role of hydrophobicity variants and other enriched mAb proteoforms on filterability through a virus filter with productivity improvement measures

Biotechnology Progress, EarlyView.
Abstract A rapid assessment of manufacturability for drug candidates is crucial for advancing a prospective biotherapeutic from a candidate to a bulk drug substance. A lot‐to‐lot approach to manufacturability is adopted where each biologic batch is assessed for manufacturability as a bulk, unfractionated pool.
Solomon Isu, Derek Silva, Melissa Holstein, Angela Lewandowski, Kristina Cunningham, Adam Sokolnicki, Bala Raghunath   +6 more
wiley   +1 more source

Capsid Structure of the Fish Pathogen Syngnathus Scovelli Chapparvovirus Offers a New Perspective on Parvovirus Structural Biology

Viruses
Chapparvoviruses (ChPVs) comprise a divergent lineage of the Parvoviridae ssDNA virus family and evolved to infect vertebrate animals independently from the Parvovirinae subfamily.
Judit J. Penzes, Jason T. Kaelber
doaj   +1 more source

A screening for canine distemper virus, canine adenovirus and carnivore protoparvoviruses in Arctic foxes (Vulpes lagopus) and red foxes (Vulpes vulpes) from Arctic and sub-Arctic regions of Norway

Polar Research, 2018
Canine distemper virus (CDV), canine adenovirus (CAdV) and canine parvovirus type 2 (CPV-2) cause disease in dogs (Canis familiaris). These, or closely related viruses, may also infect wild carnivores. The aim of this study was to investigate exposure to
Morten Tryland, Andrea Balboni, Siw Turid Killengreen, Torill Mørk, Ole Nielsen, Nigel Gilles Yoccoz, Rolf Anker Ims, Eva Fuglei   +7 more
doaj   +1 more source

Investigation into Parvovirus B19 Antibodies in Serum Samples Sent with Pre-diagnosis of Arthritis-Arthralgia

The Anatolian Journal of Family Medicine, 2020
INTRODUCTION[|]Parvovirus B19 belonging to the Erythrovirus genus is a single-stranded DNA virus in the family Parvoviridae. The present study aims to determine parvovirus B19 seropositivity in serum samples sent with pre-diagnosis of arthritis ...
Hilal Türkmen Albayrak, Ayfer Bakır, Mustafa Güney, Mehmet Tevfik Yavuz   +3 more
doaj   +1 more source

Performance of large virus removal filters during AAV processing: Influence of flux and process disruptions

Biotechnology Progress, EarlyView.
Abstract As adeno‐associated viral vectors (AAV) continue to advance through the clinical pipeline, effective downstream purification strategies must be developed to ensure bulk drug purity and safety. AAV are produced within mammalian cells, bringing forth risks associated with viral contamination.
Akshay S. Chaubal, Asingsa W. Arachchige, Annabelle J. Zahn, S. Ranil Wickramasinghe, Xianghong Qian, Andrew L. Zydney   +5 more
wiley   +1 more source

Acute Liver Failure Secondary to Hemophagocytic Lymphohistiocytosis during Pregnancy. [PDF]

, 2016
Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of excessive immune activation that mimics and occurs with other systemic diseases. A 35-year-old female presented with signs of viral illness at 13 weeks of pregnancy and progressed to acute liver ...
Decker, Kerry A, Fix, Oren K, Giard, Jeanne-Marie, Gill, Ryan M, Lai, Jennifer C, Logan, Aaron C   +5 more
core   +1 more source

Infection rate of canine parvovirus in dogs presented at private veterinary clinics in Baghdad city

Open Veterinary Journal
Background: Canine parvovirus is the primary etiology of hemorrhagic diarrhea and mortality in puppies worldwide. Aim: This study was designed to investigate canine parvovirus in dogs in Baghdad by rapid testing.
Khalid Ismael Oleiwi, Mohammed Ali Hussein, Omar Attalla Fahad, Sura Osamah Abdulrazzaq   +3 more
doaj   +1 more source

Prenatal Exome Sequencing Identifies Dual Maternal‐Fetal Diagnosis of HbF Mission Bay, a Novel HBG2 Variant Associated With Methemoglobinemia, Hypoxia and Hemolytic Anemia

Prenatal Diagnosis, EarlyView.
ABSTRACT Prenatal exome sequencing (ES) can establish rare genetic diagnoses in a fetus but may also lead to occult genetic diagnosis in a biological parent. We present a case of dual fetal and maternal diagnosis by prenatal ES, in a fetus with unexplained anemia and in a pregnant patient with sickle cell disease (SCD) and recurrent unexplained hypoxia.
Matthew A. Shear, Billie Lianoglou, Ugur Hodoglugil, W. Patrick Devine, Ashutosh Lal, Juan Gonzalez, Teresa N. Sparks   +6 more
wiley   +1 more source

Acute hepatitis and myositis associated with Erythema infectiosum by Parvovirus B19 in an adolescent [PDF]

, 2014
Background: Erythema infectiosum is the most common clinical manifestation of Parvovirus B19 infection although it has also been associated with rheumatologic diseases and various types of systemic vasculitides.
Bashiardes, Stavros, Christodoulou, Christina, Karaoli, Evaggelia, Koliou, Maria, Pavlides, Sylvie, Soteriades, Elpidoforos S   +5 more
core   +1 more source

Parvovirus-B19 and hematologic disorders

Turkish Journal of Hematology, 2010
Parvovirus-B19 (PV-B19) küçük bir DNA virusu olup Parvoviridia ailesinin bir üyesidir. PV-B19 ile ilgili hastalıklar virus, konakçı cevabı ve immun sistem etkileşmesini temsil eden iyi birer örnektir. PV-B19 ilişkili hastalıklar, çocukluk çağında eritema
Sevgi Yetgin, Selin Aytaç Elmas
doaj   +3 more sources