Results 251 to 260 of about 1,345,578 (303)
Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone +8 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Considerable efforts have been dedicated to developing effective treatments for post‐stroke executive impairment (PSEI), among which repetitive transcranial magnetic stimulation (rTMS) has shown great potential. This study aimed to investigate the therapeutic effects of high‐frequency rTMS on working memory (WM) and response ...
Mengting Lao +6 more
wiley +1 more source
[18F]Fluorodeprenyl‐D2 PET as a Tool to Monitor Disease Activity in GAD65‐Ab Autoimmune Encephalitis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To evaluate [18F]fluorodeprenyl‐D2 ([18F]F‐DED) positron‐emission tomography (PET) imaging as a biomarker of disease activity in autoimmune encephalitis (AIE) associated with glutamic acid decarboxylase 65 (GAD65) antibodies. Methods [18F]F‐DED PET was performed in 25 GAD65‐AIE patients and 8 controls using dynamic (0–60 min) and ...
Julia S. Dorneich +19 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To (1) validate GAD65‐ELISA detection and quantification for type 1 diabetes mellitus and autoimmune neurological diagnoses, (2) correlate ELISA results (reference range < 5 IU/mL) with established radioimmunoprecipitation assay (RIA; ≤ 0.02 nmol/L), and (3) define ELISA clinical utility and pitfalls.
Andrew McKeon +11 more
wiley +1 more source
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Trends in Biochemical Sciences, 2019
mRNAs move to the right place in cells to facilitate localized translation. The pathway of mRNA movement involves nuclear and cytoplasmic puncta not surrounded by investing membranes. Discoveries reported by Hondele et al. explain how mRNA molecules can be passed from one puncta to another, forming a relay that directs mRNAs to their proper location.
null Rosenblum, null Harris
+5 more sources
mRNAs move to the right place in cells to facilitate localized translation. The pathway of mRNA movement involves nuclear and cytoplasmic puncta not surrounded by investing membranes. Discoveries reported by Hondele et al. explain how mRNA molecules can be passed from one puncta to another, forming a relay that directs mRNAs to their proper location.
null Rosenblum, null Harris
+5 more sources
Science's STKE, 2006
In the immune system, B cells and T cells both recognize antigen and are thought to do so by distinct means. T cells require specialized antigen-presenting cells, called dendritic cells (DCs), to pick up protein at peripheral tissues, which they then process and present as peptides to T cells within the organized lymphoid tissues.
openaire +2 more sources
In the immune system, B cells and T cells both recognize antigen and are thought to do so by distinct means. T cells require specialized antigen-presenting cells, called dendritic cells (DCs), to pick up protein at peripheral tissues, which they then process and present as peptides to T cells within the organized lymphoid tissues.
openaire +2 more sources