Results 81 to 90 of about 7,171 (165)

Integrated Population Pharmacokinetic, Pharmacodynamic, and Safety Analyses to Inform Dosage Selection in the Clinical Development of the ATR Inhibitor Tuvusertib

Clinical Pharmacology &Therapeutics, Volume 119, Issue 3, Page 618-628, March 2026.
We present model‐informed selection of the recommended dose for expansion (RDE) of investigational oral ATR inhibitor tuvusertib, by integrating clinical pharmacokinetics (PK), pharmacodynamics (PD), and safety data from DDRiver Solid Tumors 301 trial Part A1 (NCT04170153).
Jatinder Kaur Mukker, Paul Matthias Diderichsen, Farina Hellmann, Timothy A. Yap, Ruth Plummer, Anthony W. Tolcher, Johann S. de Bono, Ioannis Gounaris, Zoltan Szucs, Astrid Zimmermann, Irina Kareva, Jayaprakasam Bolleddula, Annick Seithel‐Keuth, Giuseppe Locatelli, Marta Enderlin, Christine Hicking, Anup Zutshi, Wei Gao, Rainer Strotmann, Lisa Benincosa, Karthik Venkatakrishnan   +20 more
wiley   +1 more source

Issue when expressing a recombinant protein under the control of p35S in Nicotiana tabacum BY-2 cells. [PDF]

Front Plant Sci, 2023
Navarre C, Orval R, Peeters M, Bailly N, Chaumont F.   +4 more
europepmc   +1 more source

The power of ionic movements in plants

New Phytologist, Volume 249, Issue 5, Page 2232-2240, March 2026.
Summary The movement of ion‐driven electrogenic events known as plant action potentials in the Venus flytrap Dionaea muscipula has first been recognized in Darwin's time. Besides electrophysiological techniques making use of current‐ and voltage‐recording electrodes, today an ever‐growing spectrum of tools has become available, that report online ...
Rainer Hedrich, Ines Kreuzer
wiley   +1 more source

Martian Atmospheric Loss Through Foreshock Transient Events

Geophysical Research Letters, Volume 53, Issue 4, 28 February 2026.
Abstract At Mars, the MAVEN spacecraft has made observations of Hot Flow Anomalies (HFAs) in the foreshock. Due to the bow shock's proximity to the planet, it is theorized that HFAs contribute to atmospheric escape at Mars through the excavation of ionospheric ions.
Alexandros C. Cooke‐Politikos, Sergey Shuvalov, Yaxue Dong, Yi Qi, David A. Brain, Jasper S. Halekas   +5 more
wiley   +1 more source

Reconstructing the Geometry of a Hot Flow Anomaly With Bounding Jets in Magnetosheath

Geophysical Research Letters, Volume 53, Issue 3, 16 February 2026.
Abstract When interplanetary magnetic field discontinuities interact with planetary bow shocks, hot flow anomalies (HFAs) form in the solar wind and can extend into the magnetosheath. Here we reconstruct the three‐dimensional geometry of an HFA bounded by two jet regions in the terrestrial magnetosheath.
Yufei Zhou, Boyi Wang, Savvas Raptis, Shan Wang, Jin Guo, Jih‐Hong Shue, David Sibeck, Quanming Lu, Jiamei Zhang, Chao Shen, Rungployphan Kieokaew, C. Philippe Escoubet, Peng Shao, James Burch   +13 more
wiley   +1 more source

Laser Ablation Sampling With Low‐Power Plasma: A LA‐MIP‐MS Instrument for Spaceflight

Rapid Communications in Mass Spectrometry, Volume 40, Issue 3, 15 February 2026.
ABSTRACT Rationale Inductively coupled plasma (ICP) is a commonly used ion source for mass spectrometry‐based chemical analysis of a wide range of materials. Traditional ICP ion sources use high power (> 1000 W) and significant gas flow (> 10 L/min), rendering them unsuitable for spaceflight, as they are too resource‐intensive for planetary spacecraft.
Benjamin J. Farcy, Jacob Graham, Madeline Raith, Ricardo Arevalo Jr., Mazdak Taghioskoui, Sierra Budinoff, Amy McAdam, Jane Lee, Ryan M. Danell, Desmond A. Kaplan, Cynthia Gundersen, William F. McDonough   +11 more
wiley   +1 more source

Circulating Metabolites Treat Human TMJ‐OA by Eliminating Senescent Chondrocytes via the C1QBP/C1q/p14ARF Axis

Journal of Extracellular Vesicles, Volume 15, Issue 2, February 2026.
ABSTRACT Temporomandibular joint osteoarthritis (TMJ‐OA) is a progressive degenerative disorder, for which therapeutic interventions remain limited. The disruption of metabolic homeostasis plays a critical role in the pathogenesis and advancement of TMJ‐OA.
Bowen Meng, Xin Li, Benyi Yang, Yan Qu, Yifan He, Chaoran Fu, Zhe An, Antong Wu, Yuzhuo Hei, Rong Zhang, Wenyi Cai, Lingyunbo Kong, Rui Li, Meng Hao, Zeyuan Cao, Xueli Mao, Janak Lal Pathak, Yang Cao, Songtao Shi, Qingbin Zhang   +19 more
wiley   +1 more source

Raman Spectroscopic Analysis and In Situ Heating Experiments on Adranosite Minerals

Journal of Raman Spectroscopy, Volume 57, Issue 2, Page 343-359, February 2026.
This study provides the first detailed Raman spectroscopic characterization of rare ammonium sulfates adranosite, iron‐rich adranosite, and adranosite‐(Fe) from volcanic and coal‐fire environments. Distinct spectral features reveal compositional differences and structural effects of Fe substitution.
Filip Košek, Dávid Szabó, Máté Biró, Adam Culka, Ivan Němec   +4 more
wiley   +1 more source

Advances in Therapeutic Antibody Discovery and Development Targeting G Protein‐Coupled Receptors

Pharmacology Research &Perspectives, Volume 14, Issue 1, February 2026.
ABSTRACT G protein‐coupled receptors (GPCRs) are integral to numerous biological processes and are associated with various diseases across all therapeutic areas. Consequently, GPCRs present substantial potential for antibody‐based therapies. This review offers an overview of the therapeutic GPCR‐antibody target landscape and examines the diversity ...
Catherine J. Hutchings, Serbülent Ünsal, Mathieu Rappas, Matthew Barnes, Maria Waldhoer, Ben Holland, Martin Culka   +6 more
wiley   +1 more source

Deriving new mixing ratios for Venus atmospheric gases using data from the Pioneer Venus Large Probe Neutral Mass Spectrometer. [PDF]

MethodsX, 2023
Mogul R, Avice G, Limaye SS, Way MJ.
europepmc   +1 more source