Results 81 to 90 of about 167,905,385 (213)

The Hero’s Journey of Kamado Tanjirou in Demon Slayer: Kimetsu no Yaiba [PDF]

open access: yes, 2020
Due to globalization, the popularity of manga and anime have increased remarkably. Manga refers to Japanese comic books, the series of which are often made into Japanese cartoons, usually called anime. Although several academic studies have used manga as
Ikhtiari, Savitri Khairunnisa   +1 more
core   +2 more sources

Relativistic Thermodynamics and the Passage of Time

open access: yesHumana.Mente: Journal of Philosophical Studies, 2018
The debate about the passage of time is usually confined to Minkowski‟s geometric interpretation of space-time. It infers the block universe from the notion of relative simultaneity.
Friedel Weinert
doaj  

Recent Trends in the Philosophy of Time: an Introduction to Time and Reality I

open access: yesManuscrito
This essay is an introduction to Time and Reality I, the first part of a special issue dedicated to the philosophy of time. Here I outline a number of new trends in philosophical theorizing about time, detailing how the various contributions fit into the
Emiliano Boccardi
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Martingales and First Passage Times of AR(1) Sequences [PDF]

open access: yes
Using the martingale approach we find sufficient conditions for exponential boundedness of first passage times over a level for ergodic first order autoregressive sequences (AR(1)).
Alex Novikov, Nino Kordzakhia
core  

Second Language Acquisition in Cognitive Perspective: An Analysis of Mid-Pause of L2 Learners

open access: yes, 2019
This study examines the relationship between narrative structure (tight and loose), English proficiency (Intermediate and Higher Intermediate) and the distributions of mid-pause of English students at Indonesia University of Education. This study employs
Parwati, Eka
core   +1 more source

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