Results 231 to 240 of about 93,641 (288)

MTAP Deficiency as a Metabolic Vulnerability in Cancer: Implications for Synthetic Lethal Therapy

Cancer Science, EarlyView.
MTAP deletion creates a therapeutically actionable metabolic vulnerability through MTA accumulation and PRMT5 dependency. This review summarizes the biochemical basis of MTAP‐directed synthetic lethality, emerging PRMT5/MAT2A inhibitors, clinicogenomic features of MTAP‐deleted tumors, and future strategies for precision oncology.
Hiroaki Ikushima, Hidenori Kage
wiley   +1 more source

Resolving the Vagueness of Quantifiers With Explicit Expectations. [PDF]

Open Mind (Camb)
Reese SJ, Jasbi M, Morgan E.
europepmc   +1 more source

FluidMap: Proportional and Spatially Consistent Layout Enrichments in Multidimensional Projections

Computer Graphics Forum, EarlyView.
FluidMap faithfully represents the frequency of an attribute and preserves spatial consistency. Current space‐filling methods over‐ or under‐represent attribute categories (i.e., all Voronoi‐based methods), sacrifice spatial consistency (i.e., Nmap) or both (i.e., Voronoi‐MWα).
Daniela Blumberg, Patrick Paetzold, Michael Stroh, Oliver Deussen, Daniel A. Keim, Frederik L. Dennig   +5 more
wiley   +1 more source

Enhancing Flight Connectivity via Synchronization of Arrivals and Departures in Hub Airports with Evolutionary and Swarm-Based Metaheuristics. [PDF]

Biomimetics (Basel)
Demir HI, Dervis S.
europepmc   +1 more source

Self‐supervised Learning of Fine‐to‐Coarse Cuboid Shape Abstraction

Computer Graphics Forum, EarlyView.
Abstract The abstraction of 3D objects with simple geometric primitives like cuboids allows us to infer structural information from complex geometry. It is important for 3D shape understanding, structural analysis and geometric modeling. We introduce a novel fine‐to‐coarse self‐supervised learning approach to abstract collections of 3D shapes.
Gregor Kobsik, Morten Henkel, Yanjiang He, Victor Czech, Tim Elsner, Isaak Lim, Leif Kobbelt   +6 more
wiley   +1 more source

Passengers as Pathways: Behavioral Evidence on Travelers' Knowledge of African Swine Fever Introduction Through Pork Products. [PDF]

Vet Sci
Mandas D, Murgia G, Usai K, Bazzardi R, Muroni G, Cappai S, Coccollone A, Loi F.   +7 more
europepmc   +1 more source

Evaluating Encodings for Bivariate Edges in Adjacency Matrices

Computer Graphics Forum, EarlyView.
Abstract We present the first empirical evaluation of techniques for encoding distributions of quantitative edge values within adjacency matrices. In many real‐world networks, edges represent not a single value but a set of measurements. While adjacency matrices preserve structural clarity, their compact cells limit the simultaneous display of multiple
J. Acosta‐Hernández, A. Lex, T. He
wiley   +1 more source

Study on the adaptability of multilayer subway network under sudden large passenger flow disturbances. [PDF]

PLoS One
Lin NN, Yuan HW, Huang HT, Liu ZG.
europepmc   +1 more source

Steep declines of colonial wading birds in northeastern North America's largest breeding population

Conservation Science and Practice, EarlyView.
This study analyzed 22 years of complete nest census data for colonial wading birds in New York–New Jersey Harbor, the largest breeding population in the northeastern United States. Over this period, the total wading bird population decreased by 27%, a rate exceeding average long‐term declines across North American birds.
Dustin Partridge, Shannon R. Curley, Tod Winston, José R. Ramírez‐Garofalo, Michael C. Allen, Emilio Tobón, Paul Kerlinger, Elizabeth Craig, Susan B. Elbin   +8 more
wiley   +1 more source