Results 91 to 100 of about 374,113 (294)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Preserving buildings: emission reductions from circular economy strategies in Austria

Buildings & Cities
Buildings exert substantial pressure on global resources and contribute significantly to waste and greenhouse gas (GHG) emissions. With ambitious targets like Austria’s aim for climate neutrality before 2050, assessing the large-scale potential of ...
Nicolas Alaux, Veronika Kulmer, Johanna Vogel, Alexander Passer   +3 more
doaj   +1 more source

Depredación de Anolis porcatus (Squamata: Dactyloidae) por Passer domesticus (Aves: Passeriformes) en Cuba

Novitates Caribaea, 2017
Se registra el segundo caso en Cuba de depredación de lagartos anolinos por el Gorrión Común, Passer domesticus (Linnaeus, 1758) y se documenta fotográficamente.
Jorge Luis Guerra Solana, Luis F. de Armas   +1 more
doaj   +1 more source

Alzheimer's disease-like alterations in peripheral cells from presenilin-1 transgenic mice [PDF]

, 2006
Many cases of early-onset inherited Alzheimer's disease (AD) are caused by mutations in the presenilin-1 (PS1) gene. Expression of PS1 mutations in cell culture systems and in primary neurons from transgenic mice increases their vulnerability to cell ...
Czech, Christian, Eckert, Anne, Leutner, Silke, Luckhaus, Christian, Müller, Walter E., Schindowski, Katharina, Touchet, Nathalie   +6 more
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Material- and stock-level environmental impact assessment of two circular carbon reduction strategies applied to the European building sector

Developments in the Built Environment
The uptake of renewable energy sources (RES) and recycled content (RC) in the manufacturing of nine construction materials is modelled at the material and building stock level, evaluating 19 environmental indicators with an LCA approach.
Giulia Pristerà, Nicolas Alaux, Alexander Passer, Karen Allacker   +3 more
doaj   +1 more source

Décloisonner et « faire passer » des savoirs

Revue d'anthropologie des connaissances, 2017
Conducted by Marion Guenot and Rémi Rouge, this collective interview with Maxime Cervulle, Cornelia Möser and Arthur Vuattoux propounds a reflexive approach of the three studies they are involved in (respectively cultural studies, gender studies and on ...
Marion Guenot, Rémi Rouge
doaj   +1 more source

Forgotten Motives: the Varieties of Scientific Experience

, 2014
Personal recollections about Alexandre Grothendieck and early days of his theory of motivesComment: 10 pages. Small corrections inserted. Published in: "Alexandre Grothendieck: A Mathematical Portrait." Ed.
Manin, Yuri I.
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source