Results 31 to 40 of about 49,441 (308)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Linking vegetation indices and land tenure to assess passive restoration dynamics in the Brazilian Cerrado [PDF]

open access: yes
The Cerrado biome, a biodiversity hotspot, faces challenges such as soil degradation and water resource depletion. Passive restoration is a strategy used to recover its ecosystem, with remote sensing technology enabling monitoring of forest recovery and ...
Tonello, Kelly Cristina   +5 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Achieving a holistic view of the life cycle performance of existing dwellings

open access: yes, 2013
Models which fully evaluate the life cycle energy and greenhouse gas (GHG) emissions of national housing stocks are not reported in literature. Capturing a holistic view of energy and emissions of the residential sector is an important process that can ...
Duffy, Aidan   +4 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Replication of the Warsaw Stock Exchange’s Broad Equity Market with the WIG-ESG Socially Responsible Investment Index

open access: yesGospodarka Narodowa. The Polish Journal of Economics
The aim of this study is to investigate the viability of using the Warsaw Stock Exchange’s WIG-ESG socially responsible (ethical) investing index for building a passive investment portfolio.
Jacek Tomaszewski
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Tobacco smoking and blood parameters in the kurdish population of Iran

open access: yesBMC Cardiovascular Disorders, 2023
Objective This study investigates the relationship between smoking and blood parameters in the Iranian Kurdish population. Method The current study was conducted based on the recruitment phase of the Ravansar Non-Communicable Disease (RaNCD) cohort study.
Ebrahim Shakiba   +5 more
doaj   +1 more source

The utility of different acoustic indicators to describe biological sounds of a coral reef soundscape

open access: yesEcological Indicators, 2021
Monitoring coral reefs is vital to the conservation of these at-risk ecosystems. While most current monitoring methods are costly and time-intensive, passive acoustic monitoring (PAM) could provide a cost-effective, large scale reef monitoring tool ...
Sean A. Dimoff   +5 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Home - About - Disclaimer - Privacy