Results 41 to 50 of about 7,267,132 (287)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Combo-PON OLT Transceiver Using Photonic Integration Technology

IEEE Photonics Journal, 2022
In this work, a prototype of 10G Combo-PON OLT transceiver based on photonic integrated circuits (PIC) is proposed and demonstrated. Key optical components for Combo-PON OLT transceiver, including high-power DFB laser, micro-ring modulator and WDM, have ...
Hongqing Ding, Zeru Wu, Yuanfeng Mao, Xu Wang, Qihong Wu, Yuanbing Cheng, Yanbo Li, Tianhai Chang, Ruiqiang Ji   +8 more
doaj   +1 more source

Reconfigurable nodes for passive optical networks (PON) [PDF]

, 2009
Mestrado em Engenharia Electrónica e TelecomunicaçõesRecentemente , as redes ópticas de nova geração têm sido motivo de acesa discussão nos meios científicos.
Ferreira, Marco Paulo Flores
core  

A 10 Gb/s passive-components-based WDM-TDM reconfigurable optical access network architecture [PDF]

, 2011
We propose a cost-effective, reconfigurable optical access network by employing passive components in the remote node and dual conventional optical transceivers in ONUs.
Chigo Okonkwo, Ton Koonen, Jung, Hyun Do, Tangdiongga, Eduward, Okonkwo, Chigo; id_orcid, Hyun-Do Jung, Okonkwo, Chigo, Eduward Tangdiongga, Tran, Nguyen Cac, Tangdiongga, Eduward; id_orcid, Nguyen-Cac Tran, Koonen, Ton   +11 more
core   +3 more sources

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

A 10-Gb/s 1024-way-split 100-km long-reach optical-access network [PDF]

, 2007
Optical-access networks have been developed to remove the access-network bandwidth bottleneck. However, the current solutions do not adequately address the network economics to provide a truly cost-effective solution.
Mitchell, JE, Shea, DP
core  

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

The Applications for the Calculation and Optimization of Passive Optical Networks Attenuation Characteristics

Advances in Electrical and Electronic Engineering, 2010
The passive optical networks represent modern and promising solution to meet the increasing demands on the transmission speed in access networks. These optical networks consist only of passive optical components, essential role play mainly the passive ...
Pavel Lafata, Jiri Vodrazka
doaj