Results 21 to 30 of about 11,459,123 (283)

Parametric Optimization of Linear Ball Bearing with Four-Point Connection in Steer-by-Wire Steering Column by Means of Genetic Algorithm

Applied Sciences
This paper presents the process of the optimization of linear ball bearings with four-point connection using a genetic algorithm and the finite element method.
Arkadiusz Załęski, Mirosław Szczepanik   +1 more
doaj   +1 more source

Injury Criteria Based Optimisation of Automobile Passive Safety Systems to Mitigate the Effects of Full-Frontal Automobile Collisions

, 2014
Passive safety systems such as airbags, seat belts, and interior structural design of the automobile play a significant role in injury prevention of the occupant during collisions.
Volkan Esat, Esat, Volkan
core   +1 more source

Passive safety system assessment results (Deliverable 5.4)

, 2023
In order to determine the SAFE-UP passive safety systems effectiveness, representative test cases for the relevant accident scenarios were tested in both virtual and physical environments.
Flannagan, Carol Ann Cook,, Vidal, Carles,, Davidsson, Johan,, Becker, Julian,, Kovaceva, Jordanka,, Mensa, Genis,, Östling, Martin,   +6 more
core  

Research of active safety systems for motor vehicles [PDF]

Avtomobilʹnyj Transport (Harʹkov), 2020
Problem. The causes of accidents can be different – they include a human factor and the state of the road, and meteorological conditions, it is necessary to anticipate the full range of potentially dangerous situations, in which, theoretically, can a car
Korostelev Nikolay, Hnatov Andrii
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Safety analysis of the method of implementation of crash cushions

Acta Polytechnica CTU Proceedings, 2023
The topic of the article are vehicle restraint systems. Specifically, the paper focuses on the safety analysis of the way of implementation of crash cushions.
Tereza Šimková, Michal Frydrýn
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

ASSESSMENT OF CONDENSATION HEAT TRANSFER MODEL TO EVALUATE PERFORMANCE OF THE PASSIVE AUXILIARY FEEDWATER SYSTEM

Nuclear Engineering and Technology, 2013
As passive safety features for nuclear power plants receive increasing attention, various studies have been conducted to develop safety systems for 3rd-generation (GEN-III) nuclear power plants that are driven by passive systems.
YUN-JE CHO, SEOK KIM, BYOUNG-UHN BAE, YUSUN PARK, KYOUNG-HO KANG, BYONG-JO YUN   +5 more
doaj   +1 more source