Results 21 to 30 of about 85,781 (247)

Role of Passive Safety Systems in Chinese Nuclear Power Development

Science and Technology of Nuclear Installations, 2009
Passive safety systems have been widely applied to advanced water-cooled reactors, to enhance the safety of nuclear power plants. The ambitious program of the nuclear power development in China requires reactor concepts with high safety level.
X. Cheng, Y. H. Yang, Y. Ouyang, H. X. Miao   +3 more
doaj   +1 more source

Parametric Optimization of Linear Ball Bearing with Four-Point Connection in Steer-by-Wire Steering Column by Means of Genetic Algorithm

Applied Sciences
This paper presents the process of the optimization of linear ball bearings with four-point connection using a genetic algorithm and the finite element method.
Arkadiusz Załęski, Mirosław Szczepanik   +1 more
doaj   +1 more source

Research of active safety systems for motor vehicles [PDF]

Avtomobilʹnyj Transport (Harʹkov), 2020
Problem. The causes of accidents can be different – they include a human factor and the state of the road, and meteorological conditions, it is necessary to anticipate the full range of potentially dangerous situations, in which, theoretically, can a car
Korostelev Nikolay, Hnatov Andrii
doaj   +1 more source

Safety analysis of the method of implementation of crash cushions

Acta Polytechnica CTU Proceedings, 2023
The topic of the article are vehicle restraint systems. Specifically, the paper focuses on the safety analysis of the way of implementation of crash cushions.
Tereza Šimková, Michal Frydrýn
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

ASSESSMENT OF CONDENSATION HEAT TRANSFER MODEL TO EVALUATE PERFORMANCE OF THE PASSIVE AUXILIARY FEEDWATER SYSTEM

Nuclear Engineering and Technology, 2013
As passive safety features for nuclear power plants receive increasing attention, various studies have been conducted to develop safety systems for 3rd-generation (GEN-III) nuclear power plants that are driven by passive systems.
YUN-JE CHO, SEOK KIM, BYOUNG-UHN BAE, YUSUN PARK, KYOUNG-HO KANG, BYONG-JO YUN   +5 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

The Investigation of Nonavailability of Passive Safety Systems Effects on Small Break LOCA Sequence in AP1000 Using RELAP5 MOD 4.0

Science and Technology of Nuclear Installations, 2016
The passive safety systems of AP1000 are designed to operate automatically at desired set-points. However, the unavailability or failure to operate of any of the passive safety systems will change the accident sequence and may affect reactor safety.
Anwar Hussain, Amjad Nawaz
doaj   +1 more source