Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Assessing the changes in marine microalgae diversity in the Nanji Islands Nature Reserve over the past decades using sediment eDNA [PDF]
Haotian Li +8 more
openalex +1 more source
Price Adjustment and Liquidity in a Residential Real Estate Market with an Accelerated Information Cascade [PDF]
We examine the effect of an unannounced information event, Hurricane Katrina, on the liquidity of the residential real estate market in an area proximately located to the Mississippi Gulf Coast.
Ernest W. King, Sean P. Salter
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Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
Time Variation of Liquidity in the Private Real Estate Market: An Empirical Investigation [PDF]
This paper characterizes the behavior of and evaluates competing explanations for time variation in private real estate market liquidity documented in Fisher et al. (2003).
Greg MacKinnon, Jim Clayton, Liang Peng
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ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Kashmir's Contested Pasts: Narratives, Sacred Geographies, and the Historical Imagination
, 2014 Chitralekha Zutshi
openalex +2 more sources
Iowa observation well network; past, present, and future [PDF]
, 1980 John D. Logel
openalex +1 more source
Conservation Status and Residential Transaction Prices: Initial Evidence from Dallas, Texas [PDF]
The traditional mechanisms of private covenants and public restrictions may not meet the needs of residential property owners who want to preserve a certain neighborhood style.
Darren K. Hayunga +3 more
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