Results 71 to 80 of about 597,160 (277)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Changing Pattern of Clinical Illness in Children with Group A Streptococcal Bacteremia
Canadian Journal of Infectious Diseases, 1993 Objective: To test the hypothesis that bacteremia caused by group A streptococci (gas) has become more common and the presentation of the infection more severe in the Izaak Walton Killam Hospital for Children during the past decade.
Kim J Burrows +3 more
doaj +1 more source
Traditions et modernités : Eliot face à la temporalité française
Itinéraires, 2009 Why is the concept of modernism so unusual in French literature, unlike English and American literature? Why is the concept of classicism so usual in French literature, but not in Anglo-American literature?
William Marx
doaj +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
The past hypothesis meets gravity
, 2010 The Past Hypothesis is the claim that the Boltzmann entropy of the universe was extremely low when the universe began. Can we make sense of this claim when *classical* gravitation is included in the system? I first show that the standard rationale for not worrying about gravity is too quick.
openaire +2 more sources
FEBS Open Bio, EarlyView.Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley +1 more source
Is past life regression therapy ethical?
Journal of Medical Ethics and History of Medicine, 2017 Past life regression therapy is used by some physicians in cases with some mental diseases. Anxiety disorders, mood disorders, and gender dysphoria have all been treated using life regression therapy by some doctors on the assumption that they reflect ...
Gabriel Andrade
doaj
Looking back: linking my past experience as a trainee to the pursuit of a hypothesis to improve the treatment of patients with anorexia nervosa [PDF]
, 2023 Johannes Hebebrand
openalex +1 more source
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley +1 more source