Results 191 to 200 of about 136,936 (312)

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

Giant anteaters on the move: native habitat selection and behavioral responses to land use change. [PDF]

Mov Ecol
Meiga AYY, Desbiez ALJ, Dornas RAP, Attias N, Giroux A, Valle D.   +5 more
europepmc   +1 more source

CircTspan3 Promotes Cartilage Development Through ANNEXIN A2‐Mediated Ferroptosis and Apoptosis Inhibition and Exosome‐Mediated Paracrine Signaling

Advanced Science, EarlyView.
This study reveals that XBP1s drives production of circTspan3, a circular RNA that strengthens cartilage by boosting anabolic activity and limiting cell death. Phosphorylated ANXA2 directs circTspan3 into exosomes, enabling paracrine repair. Exosomal circTspan3 expands growth‐plate cartilage and promotes in vivo regeneration, highlighting its promise ...
Yiming Pan, Fengmei Zhang, Jiayan Zhong, Qian Gong, Nana Geng, Biao Kuang, Qiumei Lan, Miao Yi, Qiqi Zeng, Cheng Chen, Mengtian Fan, Chunliang Zhao, Deping Zeng, Yu Du, Mao Nie, Zhibiao Wang, Fengjin Guo   +16 more
wiley   +1 more source

An Update of Epidemiological Trends in Enzootic Bovine Leukosis in Italy and an Analysis of Risk Factors Associated with Infection Persistence. [PDF]

Pathogens
Righi C, Iscaro C, Petrini S, Scoccia E, Pirani S, Fiorucci A, Lomolino R, Feliziani F.   +7 more
europepmc   +1 more source

Unleashing the Potential of Raman Spectroscopy to Estimate PEDOT:PSS Doping Level and Crystalline Morphology

Advanced Science, EarlyView.
Herein, the correlational changes of each PEDOT Raman peak to morphology and doping level are identified. Two equations are derived to estimate PEDOT π–π spacing and doping level from Raman spectra (from which mobility is also extracted). GIWAXS and XPS results validate the estimation equations.
Tzu‐Yi Thomas Yu, Tsu‐Yu Chou, Viktor Naenen, Bokai Zhang, Hasan Emre Baysal, Bora Bulut, Martin Rosenthal, Francisco Molina‐Lopez   +7 more
wiley   +1 more source

Spread and dynamics of Calicophoron daubneyi and Fasciola hepatica in an extensively kept water buffalo herd and suitability of an ELISA for detecting antibodies against F. hepatica. [PDF]

Parasitol Res
Wenzel C, Zablotski Y, Knubben-Schweizer G, Strube C, Weber F.   +4 more
europepmc   +1 more source

Farming the planet: 1. Geographic distribution of global agricultural lands in the year 2000

, 2008
N. Ramankutty, A. Evan, C. Monfreda, J. Foley   +3 more
semanticscholar   +1 more source

Loss of SOCS1 in Donor T Cells Exacerbates Intestinal GVHD by Driving a Chemokine‐Dependent Pro‐Inflammatory Immune Microenvironment

Advanced Science, EarlyView.
T cell‐specific Socs1 knockout leads to inflammatory differentiation of CD8+ T cells, prompting the STAT1/2 complex to drive the activation of Ccl5, Ccr5, and Cxcr3, and promoting the skewing of monocytes toward a pro‐inflammatory M1 macrophage lineage.
Zhigui Wu, Bixia Wang, Xinya Jiang, Fangqing Zhang, Qianqian Huang, Xinyi Wu, Shuang Fan, Qi Zhang, Jingrui Zhou, Jianing Tang, Xiao‐Dong Mo, Yu Wang, Ying‐Jun Chang, Huidong Guo, Xiao‐Jun Huang   +14 more
wiley   +1 more source

Structural and Functional Responses of Small Mammal Communities to Land Abandonment in a Region of High Biodiversity. [PDF]

Animals (Basel)
Lazăr A, Sandu MA, Benedek AM, Sîrbu I.   +3 more
europepmc   +1 more source

Nap1L4a Cooperates with Scl/Klf1 to Recruit H2A.Z in Mediating Interactions Among Cis‐Regulatory Elements and Transcription Required for Primitive Erythropoiesis in Zebrafish

Advanced Science, EarlyView.
Nap1l4a is required in erythropoiesis and hypoxia responses via physical interaction with Klf1 and Scl to recruit the histone variant H2A.Z. This facilitates its associated cis‐regulatory element (CRE) remodeling and the consequent chromatin assembly, and activates the transcription of erythroid lineage‐specific genes.
JiaHao Shi, FuMing Lai, Zheng Shen, XiaoYan Zhang, HanFei Wang, WenYe Liu, YunLong Wang, KuanYu Li, GuoLiang Li, YaPing Fang, Jing‐Xia Liu   +10 more
wiley   +1 more source