Results 281 to 290 of about 288,047 (359)

miR‐135a‐5p Is a Promising Target to Prevent the Glomerulosclerosis Associated with Podocyte Developmental Toxicity in Offspring Induced by Prenatal Dexamethasone Exposure

open access: yesAdvanced Science, EarlyView.
Prenatal dexamethasone exposure (PDE) programs persistent podocyte developmental injury and adult glomerulosclerosis. Mechanistically, glucocorticoid receptor (GR) binds the miR‐135a‐5p promoter and recruits the histone acetyltransferase p300, increasing promoter histone acetylation and sustaining miR‐135a‐5p expression. Elevated miR‐135a‐5p suppresses
Xiaoqi Zhao   +8 more
wiley   +1 more source

ACSL1‐Dependent Microglial Lipoimmunometabolic Reprogramming Underlies Cognitive Deficits in Alcohol Use Disorder

open access: yesAdvanced Science, EarlyView.
This study reveals that chronic alcohol exposure selectively upregulates ACSL1 expression in prefrontal cortical microglia, driving lipid metabolism reprogramming and lipid droplet accumulation, which activates the NLRP3 inflammasome and sustains neuroinflammation. To reverse this process, a dual‐targeted lipid nanoparticle, siACSL1@LNP‐MR, is designed
Liang Hao   +8 more
wiley   +1 more source

Phenolic Compounds and Derivatives in Ruminant Meat and Milk: A Systematic Review. [PDF]

open access: yesJ Agric Food Chem
Ahsin M   +5 more
europepmc   +1 more source

Grassland Management Affects Plant Leaf Nutrients Under Ambient and Future Climate. [PDF]

open access: yesEcol Evol
Herion Y   +7 more
europepmc   +1 more source

REGENERATION OF DWARF PEASHRUB (CARAGANA AURANTIACA KOEHNE) IN PASTURES OF THE INNER TIEN SHAN IN THE SUUSAMYR VALLEY

open access: diamond
S.S. KENZHEBAEV   +6 more
openalex   +1 more source

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