Results 111 to 120 of about 1,521,241 (378)

Long-acting reversible contraception by effervescent microneedle patch

Science Advances, 2019
An effervescent microneedle patch has been designed for rapid separation of drug-loaded microneedles and long-term contraception. To increase access to long-acting contraception, we developed a reversible contraceptive microneedle patch that is simple-to-
Wei Li, Jie Tang, Richard N. Terry, Song Li, Aurélie Brunie, Rebecca L. Callahan, Richard K. Noel, Carlos A. Rodríguez, S. Schwendeman, M. Prausnitz   +9 more
semanticscholar   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Ion temperatures in HIP-1 and SUMMA from charge-exchange neutral optical emission spectra [PDF]

Ion temperatures were obtained from observations of the H sub alpha, D sub alpha, and He 587.6 nm lines emitted from hydrogen, deuterium, and helium plasmas in the SUMMA and HIP-1 mirror devices at Lewis Research Center.
Lauver, M. R., Patch, R. W.
core   +1 more source

Travelling-wave similarity solutions for an unsteady shear-stress-driven dry patch in a flowing film [PDF]

, 2013
We investigate unsteady flow of a thin film of Newtonian fluid around a symmetric slender dry patch moving with constant velocity on an inclined planar substrate, the flow being driven by a prescribed constant shear stress at the free surface of the film
Duffy, B.R., Wilson, Stephen, Yatim, Y.M.   +2 more
core  

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

Assessing the effect of deposited bitumen or asphaltenes on the nitrification process in the north saskatchewan river sediment

Environmental Advances
Following oil spills, heavier compounds of oils formed oil-sediment mixtures and deposited on the riverbed, yet their impacts on freshwater sediment ecosystems are not well understood. This study aimed to (1) examine the effects of deposited bitumen (Bit)
Nayereh Saborimanesh, Patricia Q. Tran, Md Hosnay Mobarok   +2 more
doaj  

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Exploring Context with Deep Structured models for Semantic Segmentation

, 2017
State-of-the-art semantic image segmentation methods are mostly based on training deep convolutional neural networks (CNNs). In this work, we proffer to improve semantic segmentation with the use of contextual information.
Hengel, Anton van den, Lin, Guosheng, Reid, Ian, Shen, Chunhua   +3 more
core   +1 more source

Design of a Wideband Circularly Polarized Strip-Helical Antenna With a Parasitic Patch

IEEE Access, 2016
A wideband strip-helical antenna with a parasitic circular patch for circular polarization is designed in this paper. A strip-helix with 2.5 turns and a pitch angle of 5° is placed over a ground plane and coaxial probe-fed by a 50-Ω SMA ...
Xihui Tang, Yejun He, Botao Feng
doaj   +1 more source