Results 141 to 150 of about 1,521,241 (378)

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Using Polymers as Crystal Inhibitors to Prevent the Crystallization of the Rotigotine Patch

Pharmaceutics
This study aimed to enhance the stability of the Rotigotine (ROT) patch using polymers as crystal inhibitors. Three polymers (Poloxamer 188, Soluplus, TPGS) were selected as crystal inhibitors to formulate ROT patches with varying drug loadings (20%, 40%,
Qiantong Liu, Xing Li, Bo Liu, Jiahao Kong, Qing Wang, Zhigang Gao   +5 more
doaj   +1 more source

Lichen Planus with Herald Patches [PDF]

, 1936
H. W. Barber
openalex   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Proposal for the Comparison of the Magnitude Scales of the Astrographic Catalogue. Sixth Note. The Oxford Magnitudes. With a Preliminary Discussion of the Existence of Obscured Patches in the Sky [PDF]

, 1915
H. H. Turner, F. G. Brown
openalex   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Ultrasonic measurement of core material temperature Final report [PDF]

Ultrasonic measurement of core material temperature in nuclear rocket ...
Lynnworth, L. C., Patch, D. R.
core   +1 more source

MEASURING CONNECTIVITY – A NEW APPROACH FOR THE GEOMETRIZATION OF THE LANDSCAPE AND FOR THE ENHANCEMENT OF COST-EFFECTIVENESS IN LANDUSE PLANNING [PDF]

Acta Geographica Debrecina. Landscape & Environment Series, 2009
The study aims to introduce a new method and approach for measuring the diversity of connectivity with the help of the landscape geometrization, in order to create a new variable useful in landscapemetrics and to decrease the costs of landscape planning ...
GÁBOR DEMETER
doaj  

Contraception During Perimenopause: Practical Guidance

International Journal of Women's Health, 2022
Giovanni Grandi,1 Pierluigi Di Vinci,2 Alice Sgandurra,1 Lia Feliciello,1 Francesca Monari,1 Fabio Facchinetti1 1Department of Medical and Surgical Sciences for Mother, Child and Adult, University of Modena and Reggio Emilia, Azienda Ospedaliero ...
Grandi G, Di Vinci P, Sgandurra A, Feliciello L, Monari F, Facchinetti F   +5 more
doaj