Results 161 to 170 of about 424,048 (187)

Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance

Advanced Science, EarlyView.
Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer, Ian de Ridder, Mahjoobeh Ehsani, Marasim Khan, Justin Kale, Lukas P. Frenzel, David Andrews, Spyridoula Karamanou, Ana J. Garcia‐Saez, Geert Bultynck   +9 more
wiley   +1 more source

Arthroscopic Rotator Cuff Repair With a Compressed Long Head of the Biceps Tendon Interposition Graft. [PDF]

Arthrosc Tech
Gong WJ, Jiang HT, Zhu RT.
europepmc   +1 more source

SPSB1 Promotes Subcutaneous Adipose Hyperplasia in Facial Port‐Wine Stains by Controlling HDAC1 Degradation and Stability Through Two Distinct Proteolytic Pathways

Advanced Science, EarlyView.
In PWS‐ASPCs, FOSL1 drives the expression of SPSB1. SPSB1, as part of the ESC complex, further binds to HDAC1 and promotes K29‐linked and K48‐linked polyubiquitination of HDAC1. These modifications facilitate the degradation of HDAC1 through the ALP and UPS pathways, respectively.
Hongrui Chen, Bin Sun, Yajing Qiu, Chen Hua, Xiaoxi Lin, Wei Gao   +5 more
wiley   +1 more source

The Role of Carotid Graft Interposition During Elective and Emergent Interventions: Protocol for a Scoping Review. [PDF]

JMIR Res Protoc
Pasquetti L, Zlatanovic P, Pasqui E, Kostic O, Galzerano G, Koncar I, Dragas M, de Donato G.   +7 more
europepmc   +1 more source

Human Dental Pulp Stem Cell Secretome Restores Ischemic Stroke–Impaired Motor and Cognitive Functions by Reprogramming Redox and Inflammatory Signaling

Advanced Science, EarlyView.
Human dental pulp stem cell secretome emerges as a cell‐free therapeutic strategy for ischemic stroke by reprogramming redox and inflammatory signaling. hDPSC secretome‐derived antioxidant and immunomodulatory factors suppress the TLR4–NOX–ROS–NF‐κB axis, reduce microglial inflammatory responses and apoptosis, and promote neurogenesis, angiogenesis ...
Kyung‐Joo Seong, Sehoon Park, Sun‐Woong Bae, Daseul Kim, Jin Ho Lee, Won‐Seok Choi, Zee‐Yong Park, Ji‐Yeon Jung, Won‐Jae Kim   +8 more
wiley   +1 more source

Stapled bovine pericardial tube graft for infected thoracic aortic reconstruction: Geometric sizing and technical considerations. [PDF]

J Vasc Surg Cases Innov Tech
Alsahwan AG, Al-Mubarak H, Alayadhi WA, Al-Omran M, Abdulrahim O.   +4 more
europepmc   +1 more source

Herbicide Metabolic Resistance in Poaceae Plants via the GA‐GID1/DELLA‐DOF2‐P450s Module

Advanced Science, EarlyView.
Plant hormone signaling modulates herbicide resistance in Echinochloa crus‐galli. The GA–DELLA–DOF2 cascade directly activates P450 detoxification genes in two Poaceae species, uncovering a core mechanism of metabolic herbicide resistance. ABSTRACT Barnyard grass (Echinochloa crus‐galli) is one of the world's most important weeds, and the evolution of ...
Junzhi Wang, Jiale Qi, Lin Wei, Qin Yu, Zhongyuan Liu, Lianyang Bai, Lang Pan   +6 more
wiley   +1 more source

Management of double anterior chamber after deep anterior lamellar keratoplasty using descemetopexy with corneal patch: A case report. [PDF]

Am J Ophthalmol Case Rep
Izquierdo L, Icaza-Hidalgo D, Cadavid JC, Vera-Duarte GR, Henriquez MA.   +4 more
europepmc   +1 more source

A Biologic Hybrid Approach Combining Superior Capsular Reconstruction, Long Head of the Biceps Tendon Rerouting, and Rotator Cuff Repair. [PDF]

Arthrosc Tech
Kim BT, Kim HJ, Cho HW, Hong SW.
europepmc   +1 more source

Surgical and Histopathologic Insights Into Mid-Aortic Syndrome: A Case Report. [PDF]

Case Rep Surg
Hruschka B, Doukas P, Gombert A.
europepmc   +1 more source