Results 121 to 130 of about 226,989 (311)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Stability of fragrance patch test preparations applied in test chambers.

, 2012
Background: Petrolatum patch test preparations are for practical reasons often applied in test chambers in advance, several hours or even days before the patient is tested.
Svedman, Cecilia,, Bruze, Magnus,, Zimerson, Erik, Mowitz, Martin,, Lund University., Bruze, Magnus, Mowitz, Martin, Svedman, Cecilia, Zimerson, Erik,   +8 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Test patch and comparison patch.

, 2013
The observer adjusted the luminance of the comparison patch until the perceived albedo of the patches was the same.
Laurence T. Maloney (93877), Hisashi Kobiki (376688), Michiteru Kitazaki (288698)   +2 more
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Relevance of positive patch-test reactions to fragrance mix

, 2008
Background Fragrances are an important cause of allergic contact dermatitis. We presume that the traditional fragrance mix (FM) detects 70 to 80% of fragrance-allergic patients. FM has an irritant potential.
Tupker, R.A., Valk, P.G.M. van der, Devos, S.A., Kruyswijk, M.R., van der Valk, P.G.M., Constandt, L., van Zuuren, EJ, Vink, J., Bruynzeel, D.P., van, d., V, Lucker, G.P., Kiemeney, L.A.L.M., Schuttelaar, M.L.A.; id_orcid, van Zuuren, E.J., Kruyswijk, M.R.J., Noz, K.C., Coenraads, P.J., Kiemeney, L.A., Schuttelaar, M.L.A., Schuttelaar, M.L., Zuuren, E.J. van, Lucker, G.P.H., Noz, KC   +22 more
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Test-based Patch Clustering for Automatically-Generated Patches Assessment [PDF]

Previous studies have shown that Automated Program Repair (apr) techniques suffer from the overfitting problem. Overfitting happens when a patch is run and the test suite does not reveal any error, but the patch actually does not fix the underlying bug ...
Aleti, Aldeida, Sarro, Federica, Martinez, Matias, Petke, Justyna, Kechagia, Maria, Perera, Anjana   +5 more
core  

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Analysis of clinical characteristics of adverse cosmetic reactions in 1578 pediatric cases in the Chongqing area（2017 to 2024）

Pifu-xingbing zhenliaoxue zazhi
Objective To reveal the clinical characteristics of cosmetic adverse reactions （CARs）and relevant information in a pediatric population regarding pathogenic cosmetics in Chongqing from 2017 to 2024.This study aimed to provide characteristics of CARs in ...
LYU Jing, JIANG Yang, WANG Sha, LI Jiajia, CHEN Baoli   +4 more
doaj   +1 more source