Results 171 to 180 of about 110,040 (258)

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

A miniaturized wireless and passive antenna sensor with meandering structure for integrated multi-directional strain and temperature sensing. [PDF]

Microsyst Nanoeng
Guo L, Dong H, Liang S, Tian X, Fu H, Dong T, Guo L, Wu D, Tan Q.   +8 more
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Functional methods for evaluating the efficacy of retinal optogenetic therapy for vision restoration. [PDF]

Front Neurosci
Borchert GA, Shamsnajafabadi H, Xue K, MacLaren RE, De Silva SR, Cehajic-Kapetanovic J.   +5 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

A multicenter study by the Brazilian Society of Dermatology on a new standard patch test series. [PDF]

An Bras Dermatol
Bonamigo RR, Rocha VB, Reis VMSD, Rodrigues DF, Lazzarini R, Pires MC, Hikawa RS, Kiszewski AE, França AFEDC, Heck R, Scherrer MAR, Samorano LP, Cordeiro ICM, Duarte IA, Hafner MFS, Pires RMG, Eller LS, Rodrigues JB, Bumaguin DB, Hahnstadt RL.   +19 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Fatigue Life Analysis of a Plate with a Repair Node Subjected to Uniform Shear. [PDF]

Materials (Basel)
Barca I, Rośkowicz M.
europepmc   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Metal Sensitization in Patients That Underwent Patch Test Pre and Post-Implant Exposure. [PDF]

Contact Dermatitis
Zampa N, Lazzarato I, Mauro M, Tassinari A, Cegolon L, Larese Filon F.   +5 more
europepmc   +1 more source