Results 51 to 60 of about 848,646 (270)

The disproportionately high value of small patches for biodiversity conservation

Conservation Letters, 2022
Small habitat patches have been historically neglected in conservation, primarily because extinction risk is higher in small patches. Nevertheless, sets of small patches usually harbor more species than one or a few larger patches of equal total area ...
Federico Riva, Lenore Fahrig
doaj   +1 more source

Cigarette smoking alters intestinal barrier function and Peyer's Patch composition [PDF]

, 2011
Smokers have a two-fold increased risk to develop Crohn’s disease (CD). However, little is known about the mechanisms through which smoking affects CD pathogenesis. Interestingly, the Peyer’s patches in the terminal ileum are the sites where the first CD
Bracke, Ken, Brusselle, Guy, Cuvelier, Claude, Demoor, Tine, Lambrecht, Bart, Plantinga, Maud, VERSCHUERE, Stephanie   +6 more
core  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Prospective randomized study on the efficacy of three-dimensional reconstructions of bronchovascular structures on preoperative chest CT scan in patients who are candidates for pulmonary segmentectomy surgery: the PATCHES (Prospective rAndomized sTudy efficaCy of tHree-dimensional rEconstructions Segmentecomy) study protocol

Trials, 2023
Introduction Pulmonary segmentectomy, when combined with hilar and mediastinal lymphadenectomy, is currently considered the gold standard treatment for early-stage lung tumors (NSCLC) smaller than 2 cm in diameter.
Francesco Zaraca, Andreas Kirschbaum, Marco Damiano Pipitone, Luca Bertolaccini, The PATCHES study group   +4 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Impact of APOE ε4 Genotype Load on Cognitive Function and Lipid Metabolism in Patients With Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Apolipoprotein ε4 (APOE ε4) is a potent genetic risk factor for Alzheimer's disease (AD). However, its role in cerebral small vessel disease (CSVD) remains unclear. Given the clinical and pathological similarities between CSVD and AD, this study aimed to investigate the associations of APOE ε4 gene dosage with cognitive function and
Tingru Jin, Haocheng Yang, Feng Liu, Sihao Lin, Junru Hu, Jian Wang, Yulan Gou   +6 more
wiley   +1 more source

Przezskórna terapia okresu menopauzy – state of the art in 2010

Menopause Review, 2010
In this article some up-to-date information on transdermal hormone therapy is presented. Lack of first-passeffect, therapeutic efficacy and safety make transdermal MHT a therapy of the first choice for many menopausalsubjects.
Tomasz Pertyński, Grzegorz Stachowiak
doaj  

Miniaturized Microstrip Dual-Channel Diplexer Based on Modified Meander Line Resonators for Wireless and Computer Communication Technologies

Technologies
There has been a lot of interest in microstrip diplexers lately due to their potential use in numerous wireless and computer communication technologies, including radio broadcasts, mobile phones, broadband wireless, and satellite-based communication ...
Yaqeen Sabah Mezaal, Shahad K. Khaleel, Ban M. Alameri, Kadhum Al-Majdi, Aqeel A. Al-Hilali   +4 more
doaj   +1 more source

100 GHz Silicon-based micro-machined patch antenna and arrays

The Journal of Engineering, 2019
This study designs a micro-machined BCB-cavity patch antenna and two types of four-element micro-machined antenna arrays at 100 GHz. The patches are fabricated on Benzocyclobutene (BCB) polymer material.
Jingtian Liu, Shuming Chen, Ke Xiao, Xiaowen Chen   +3 more
doaj   +1 more source