Results 131 to 140 of about 1,660,326 (362)

AWARD TO THE AUTHOR (AUTHORS) IS A STIMULUS OF INVENTIVE ACTIVITY

open access: yesЛитьë и металлургия, 2010
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L. P. Ladik
doaj  

The Patent Spiral [PDF]

open access: yes, 2016
Examination — the process of reviewing a patent application and deciding whether to grant the requested patent — improves patent quality in two ways. It acts as a substantive screen, filtering out meritless applications and improving meritorious ones. It
Ford, Roger Allan
core   +2 more sources

Purification tags markedly affect self‐aggregation of CPEB3

open access: yesFEBS Letters, EarlyView.
Although recombinant proteins are used to study protein aggregation in vitro, uncleaved tags can interfere with accurate interpretation. Our findings demonstrate that His₆‐GFP and His₁₂ tags significantly affect liquid droplet and amyloid fibril formation in the intrinsically disordered region (IDR) of mouse cytoplasmic polyadenylation element‐binding ...
Harunobu Saito   +6 more
wiley   +1 more source

The Political Economy of the Research Exemption in American Patent Law [PDF]

open access: yes, 2016
This Article approaches the research exemption, and related legal developments, as a case study in the political economy of patent law. Part I recounts the history of the research exemption, touching briefly on historical origins but emphasizing ...
Short, Nicholas
core   +2 more sources

Circulating histones as clinical biomarkers in critically ill conditions

open access: yesFEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez   +17 more
wiley   +1 more source

PHARMACEUTICAL CO-CRYSTALLS. FEATURES OF ASSESING THE PATENTABILITY

open access: yesРазработка и регистрация лекарственных средств, 2019
In connection with the latest achievements of the theoretical crystallography the question of a potential patentability of new co-crystals of the known substances, as well as the estimation of their novelty and inventive step, becomes more and more ...
S. A. Sinchenko
doaj  

The Interpretation-Construction Distinction in Patent Law [PDF]

open access: yes, 2013
The ambiguity of claim language is generally considered to be the most important problem in patent law today. Linguistic ambiguity is believed to cause tremendous uncertainty about patent rights.
Chiang, Tun-Jen, Solum, Lawrence B.
core   +1 more source

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

open access: yesFEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao   +7 more
wiley   +1 more source

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