Results 141 to 150 of about 1,745,820 (365)
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
PHARMACEUTICAL CO-CRYSTALLS. FEATURES OF ASSESING THE PATENTABILITY
Разработка и регистрация лекарственных средств, 2019 In connection with the latest achievements of the theoretical crystallography the question of a potential patentability of new co-crystals of the known substances, as well as the estimation of their novelty and inventive step, becomes more and more ...
S. A. Sinchenko
doaj
Patent Thickets and the Market for Innovation: Evidence from Settlement of Patent Disputes [PDF]
We study how fragmentation of patent rights ('patent thickets') and the formation of the Court of Appeal for the Federal Circuit (CAFC) affected the duration of patent disputes, and thus the speed of technology diffusion through licensing.
Alberto Galasso, Mark Schankerman
core
Confidentiality in Patent Dispute Resolution: Antitrust implications [PDF]
, 2018 nformation is crucial to the functioning of the patent system, as it is for other markets. Nevertheless, patent licensing terms are often subject to confidentiality agreements.
Patterson, Mark R.
core +1 more source
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Patent Portfolio Races in Concentrated Markets for Technology [PDF]
Patent application numbers grow exponentially in many industries, a phenomenon that has been linked to high fragmentation of patent ownership. Contradicting these findings and theoretical arguments, we show that such fragmentation is not a precondition ...
Florian Jell, Joachim Henkel
core
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Patent and Technical Forensic Examination
Теория и практика судебной экспертизыThe article provides recommendations based on the author’s personal experience on conducting patent and technical forensic examination of inventions and utility models.
Yu. V. Grigor’ev
doaj +1 more source
Interatrial septal aneurysm associated with patent foramen ovale in a dog - case report [PDF]
, 2023 R.P.S. Rodrigues +5 more
openalex +1 more source