Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Temporary Occlusion of Patent Ductus Arteriosus in Adult during Cardiac Surgery. [PDF]
Ikemoto K +4 more
europepmc +1 more source
Constructing a Chinese Patent Database of Listed Firms in China: Descriptions, Lessons, and Insights
Zi-Lin He +3 more
semanticscholar +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
CEO greed and corporate technological innovation: Analyst coverage as an external governance mechanism in China's A-share market. [PDF]
Hu Y, Cong R, Teng R, Ji B.
europepmc +1 more source
Monocyte Chemoattractant Protein-1 and Interleukin-8 Levels in Urine and Serum of Patents with Hemolytic Uremic Syndrome [PDF]
P.A. van Setten +7 more
openalex +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Bilateral Choanal Atresia in a 65-Year-Old Female: A Case Report and Literature Review. [PDF]
Qout MA +3 more
europepmc +1 more source
N-terminal pro-B-type natriuretic peptide: a measure of significant patent ductus arteriosus [PDF]
Ireti Farombi-Oghuvbu +4 more
openalex +1 more source

