Results 101 to 110 of about 65,819 (300)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Experiments on domain adaptation for patent machine translation in the PLuTO project [PDF]

, 2011
The PLUTO1 project (Patent Language Translations Online) aims to provide a rapid solution for the online retrieval and translation of patent documents through the integration of a number of existing state-of-the-art components provided by the project ...
Tinsley, John, Zhang, Jian, Way, Andy, Ceausu, Alexandru   +3 more
core  

A Study on the Performance Improvement of Automatic Intellectual Property Counseling Classification: Using the Transformer-based AI Model BERT

Journal of Intellectual Property
Intellectual property customer counseling is an important public service that supports the creation of intellectual property rights and protection of the rights and interests of applicants and rights holders.
Dong-Hun Noh, Jae-Ok Min, So-Youn Woo
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Patent Classification Experiments with the Linguistic Classification System LCS. [PDF]

, 2010
Contains fulltext : 85896.pdf (Publisher’s version ) (Open Access)
Verberne, S., Vogel, Merijn, D'hondt, E.K.L.   +2 more
openaire   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

A patent push method and system based on the product life cycle multi-dimensional classification

Journal of Big Data
As one of the essential carriers of knowledge, patents can provide rich cross-domain knowledge support for the product innovation design process. However, the main challenge facing most patent-assisted innovation design systems is identifying and ...
Zhen Zhang, Yan Xuan
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Patent Classification Using Ontology-Based Patent Network Analysis

, 2010
Patent management is increasingly important for organizations to sustain their competitive advantage. The classification of patents is essential for patent management and industrial analysis.
Shih, Meng-Jung, Liu, Duen-Ren
core  

A study on the monitoring of technology innovation through patent analysis

Humanities & Social Sciences Communications
These days, innovation cycles are becoming shorter, and market competition has grown increasingly intense. Therefore, it is essential for companies to adopt strategic R&D approaches to remain competitive.
Junseok Lee, Sangsung Park, Juhyun Lee
doaj   +1 more source