Results 141 to 150 of about 62,342 (217)

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Descriptive CBCT Findings of Maxillary Sinus Mucosal Changes in Patients Undergoing Sinus Floor Elevation: A Retrospective Observational Study. [PDF]

Dent J (Basel)
Mckeever N, Khan R, Ucer C, Wright S, Spacey A.   +4 more
europepmc   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Predicting homologous recombination deficiency and treatment responses using a computed tomography-based foundation model: a preclinical study. [PDF]

NPJ Precis Oncol
Kuang S, Schuitmaker L, Wu M, Salahuddin Z, van der Wiel A, van de Laak J, Lieuwes N, Biemans R, Jung J, Yaromina A, Dubois LJ, Woodruff HC, Lambin P.   +12 more
europepmc   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Hybrid vision transformer framework for congenital heart disease diagnosis. [PDF]

Sci Rep
Khan K, Irfanud D, Khan RU.
europepmc   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

A pre-trained foundation model framework for multiplanar MRI classification of extramural vascular invasion and mesorectal fascia invasion in rectal cancer. [PDF]

Insights Imaging
Zhang Y, Mali SA, Khan D, Amirrajab S, Ibor-Crespo E, Jimenez-Pastor A, Ribas G, Flor-Arnal S, Zerunian M, Aubé C, Martí-Bonmatí L, Salahuddin Z, Lambin P.   +12 more
europepmc   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Experimental data reuploading with provable enhanced learning capabilities. [PDF]

Sci Adv
Mauser MFX, Four S, Predl LM, Albiero R, Ceccarelli F, Osellame R, Petersen P, Dakić B, Agresti I, Walther P.   +9 more
europepmc   +1 more source