Results 111 to 120 of about 3,213,706 (247)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Applied SciencesPatent retrieval is important for innovation management, R&D planning, and intellectual property strategy, yet conventional searches are hindered by terminology variability, synonymy, broad patent scopes, and classification limitations.
Federico Rotini +2 more
doaj +1 more source
Search system requirements of patent analysts
, 2010 Patent search tasks are difficult and challenging, often requiring expert patent analysts to spend hours, even days, sourcing relevant information. To aid them in this process, analysts use Information Retrieval systems and tools to cope with their ...
Wim Vanderbauwhede +6 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Elements of Strategic Planning of Patent Protection for Pharmaceutical Inventions
Регуляторные исследования и экспертиза лекарственных средствINTRODUCTION. The commercial success of innovations in medicine and pharmaceutics depends on the strategic planning of patent protection, with the main elements for consideration being the type of patent protection, the scope of the invention, and the ...
M. Yu. Anikeeva +2 more
doaj +1 more source
Technology Adoption and Fuzzy Patent Rights [PDF]
, 2010 This paper considers why a patentee may have little incentives to reduce the uncertainty of patent boundary. Clearer patent rights, i.e., when patent examination results better predict subsequent court decisions, provide better guidance to ...
Chiou, Jing-Yuan
core
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Google Patents: The global patent search engine [PDF]
, 2014 Google Patents (www.google.com/patents) includes over 8 million full-text patents. Google Patents works in the same way as the Google search engine. Google Patents is the global patent search engine that lets users search through patents from the USPTO ...
Noruzi, Alireza, Abdekhoda, Mohammadhiwa
core +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source