Results 141 to 150 of about 40,494 (265)

Monogenic and syndromic obesity in children: Clinical recognition, genetics, and precision management

open access: yesPediatric Investigation, EarlyView.
Monogenic and syndromic obesity in children often arises from defects in the leptin–melanocortin pathway. Understanding these rare genetic causes not only clarifies mechanisms of appetite regulation but also enables precision therapies, offering hope beyond lifestyle interventions.
Hadel Khalil   +2 more
wiley   +1 more source

Parental body mass index and offspring childhood body size and eating behaviour: A structural equation modelling analysis in the Norwegian Mother, Father and Child Cohort Study. [PDF]

open access: yesPLoS Med
Bond TA   +11 more
europepmc   +1 more source

Multiple Roles of Protamine Kinase SRPK1 and Phosphatase PP1γ in Sperm Development

open access: yesPROTEOMICS, EarlyView.
ABSTRACT Protein phosphorylation regulates key events of male germ cell differentiation. In the testis, SRPK1 and PP1γ are involved in protamine phosphorylation and dephosphorylation, respectively, and their deregulation is linked to defective chromatin structure and male infertility.
Alberto de la Iglesia   +7 more
wiley   +1 more source

Dietary restriction induces persistent multigenerational phenotypic effects in Phytoseiulus persimilis

open access: yesPest Management Science, EarlyView.
The study shows ancestral dietary restriction in Phytoseiulus persimilis produces persistent, sex‐specific, multi‐generational effects on survival and body size, with stronger maternal than paternal lineage influences despite nutritional recovery. Abstract BACKGROUND Transgenerational phenotypic plasticity (TGP) allows environmental effects to persist ...
Xia Chen   +4 more
wiley   +1 more source

Nanomaterials' Multigenerational Effects by Single and Joint Exposure in Non‐mammalian Models

open access: yesEnvironmental Toxicology, EarlyView.
ABSTRACT Nanotoxicology has mainly focused on single‐generation studies, leaving multigenerational toxicity underexplored. Having animal welfare recently gained importance, we aimed to provide the state‐of‐the‐art of knowledge about multigenerational effects in non‐mammalian models in the case of nanomaterials (NM) single and joint exposure to other ...
Andy Joel Taipe Huisa   +9 more
wiley   +1 more source

Paternal Postpartum Depression in South Asia. [PDF]

open access: yesPublic Health Chall
Yasir Arafat SM, Hossain S.
europepmc   +1 more source

Exploring Interactive Effects of Arsenic and Selenium Exposure on Larval Zebrafish (Danio rerio)

open access: yesEnvironmental Toxicology, EarlyView.
ABSTRACT Arsenic contamination in aquatic ecosystems is a major environmental concern. Selenium (Se) helps mitigate oxidative stress and hence could reduce the toxic effects of arsenic. However, Se can also be toxic at high concentrations. Given that these metalloids commonly co‐occur in the environment, there is a pressing need for further research ...
Owen Luo   +6 more
wiley   +1 more source

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