Results 41 to 50 of about 14,133 (214)

Paternal use of metformin and risk of major congenital malformations: A meta‐analysis of 4 studies

British Journal of Clinical Pharmacology, EarlyView.
Abstract Metformin is the first‐line drug for the treatment of Type 2 diabetes. In 2022, a Danish registry‐based study reported a 40% increased risk of major congenital malformations following paternal exposure during spermatogenesis. This raised widespread concern about the use of metformin in males of reproductive age.
Per Damkier, Marleen M. H. J. van Gelder, Krista F. Huybrechts, Lin‐Chieh Meng, Sonia Hernandez‐Diaz, Jan Nielsen, Bente M. Nørgård, Hedvig Nordeng   +7 more
wiley   +1 more source

Affective Paternalism

In this commentary we expand on the special issue themes of applied affective science, ecologically valid data and application, and the need for transdisciplinary collaboration by discussing and exemplifying how affective science can inform behavioral public policy.
Daniel Västfjäll, Erkin Asutay, Gustav Tinghög   +2 more
openaire   +1 more source

Leaving children behind for cross‐border education: Unveiling the emotional agency of international post‐graduate student mothers

British Educational Research Journal, EarlyView.
Abstract Despite growing interest in the internationalisation of higher education, the experiences of international student parents, particularly international student mothers, remain largely marginalised in research and policy. This paper examines the emotional agency of international student mothers who leave their children behind in their home ...
Anh Ngoc Quynh Phan, Ha Ngan Ngo, Chloe Le   +2 more
wiley   +1 more source

Predictors of authorised, unauthorised and persistent absence among secondary school pupils in Scotland

British Educational Research Journal, EarlyView.
Abstract This article examines the factors associated with persistent absenteeism (an absence rate of 10% or higher) and authorised and unauthorised absence among secondary school pupils in Scotland. Using linked administrative data, the analysis focuses on secondary school stages S1–S6 in three academic years.
Silvia Behrens, Morag Treanor, Patricio Troncoso, Bethany Lee‐Shield, Emma Russell, Lee Williamson, Cecilia Macintyre   +6 more
wiley   +1 more source

Migrant success in UK Education: Are there lessons for government social mobility policy?

British Educational Research Journal, EarlyView.
Abstract The school achievement and career aspirations of 23 sixth form students at a multi‐cultural urban academy in the UK are explored through interviews. The sample includes 16 s‐generation migrants, 6 UK‐born students with migrant parents and 1 UK‐born student, selected to represent a cohort of over 300 post‐16 learners.
Bernard Barker, Kate Hoskins
wiley   +1 more source

Placental crises: disruptive selection and maternal under‐investment as the foundations of mammalian placental evolution and dysfunction

Biological Reviews, EarlyView.
ABSTRACT Among the vertebrates, mammals are notable for the dominance of live birth and placental nutrition. The structural diversity of the mammalian placenta is remarkable, despite sharing a single common ancestor and conserved physiological functions.
Davis Laundon, Neil J. Gostling, Ian G. Reddin, Bram G. Sengers, Pascale Chavatte‐Palmer, Rohan M. Lewis   +5 more
wiley   +1 more source

The costs of extra‐pair behaviours in birds

Biological Reviews, EarlyView.
ABSTRACT Extra‐pair behaviours – reproductive behaviours, including those related to copulation and paternity of offspring, amongst animals outside of a social pair bond – have long intrigued behavioural ecologists, particularly from the female animal's perspective.
Jørgen S. Søraker, Jamie Dunning
wiley   +1 more source

Performative paternalism

European Journal for Philosophy of Science
Abstract Performativity of science refers to the phenomenon that the dissemination of scientific conceptualisations can sometimes affect their target systems or referents. A widely held view in the literature is that scientists ought not to deliberately deploy performative models or theories with the aim of eliciting desirable changes in ...
openaire   +2 more sources

PEK14: A Kinesin‐4 Necessary for Male‐Derived Fertility in Arabidopsis thaliana

Cytoskeleton, EarlyView.
ABSTRACT Of the 61 kinesins annotated in Arabidopsis thaliana, many are still without assigned function. Here, we have screened an insertional mutant library of Arabidopsis pollen‐expressed kinesins for fertility defects. Insertional mutants for three kinesins showed a significant reduction in seed set.
Isabella N. Mendes, Norman R. Groves, Jessica Z. Li, Lily N. Thompson, Brian J. Smith, Aman Y. Husbands, Iris Meier   +6 more
wiley   +1 more source

PharmVar GeneFocus: CYP1A2—Clinical Impact, Genetic Variation, and Updated Nomenclature

Clinical Pharmacology &Therapeutics, EarlyView.
The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly polymorphic human CYP1A2 gene. CYP1A2 plays a crucial role in the biotransformation of several commonly used drugs, including antipsychotics, antidepressants, anxiolytics, and methylxanthines.
Katalin Monostory, Gonzalo Villapalos Garcia, Dora Koller, Solomon Adams, Chad A. Bousman, Evangelia Eirini Tsermpini, Michelle Whirl‐Carrillo, Amy J. Turner, Volker M. Lauschke, Mohamed Nagy, Erin C. Boone, Teri E. Klein, Pablo Zubiaur, Andrea Gaedigk   +13 more
wiley   +1 more source