Results 31 to 40 of about 2,019 (207)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Path Dependence in Sovereign Debt Modelling: System Dynamics Approach

Наукові записки НаУКМА: Економічні науки, 2021
The article offers a system dynamic modelling of sovereign debt using the path dependence concept. Using simulation modelling we are trying to find a fixed point in a motion of national sovereign debt towards its equilibrium and to change the existing ...
Hennadiy Hryhoriev
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

As a Chinese researcher in Belgium: Path dependence or path-breaking?

Belgeo
Extra-regional linkages contribute to innovation. However, detailed thoughts of innovators are missing in the literature. A question arises: how does a newly established extra-regional linkage affect knowledge production?
Fan Xiao
doaj   +1 more source

Aspetti di lungo periodo della crisi economica Italiana attraverso le lenti di Paolo Sylos Labini (Long-term aspects of the Italian economic crisis through the lenses of Paolo Sylos Labini)

Moneta e Credito, 2021
Nell’ambito del dibattito sulla crisi dell’economia italiana il pensiero di Paolo Sylos Labini si impone per la straordinaria attualità, recuperando i riferimenti concettuali e la visione dinamica dello sviluppo economico propri degli economisti ...
Daniela Palma
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Path Dependence from Proxy Agent to De Facto State: A History of ‘Strategic Exploitation’ of the Kurds as a Context of the Iraqi Kurdistan Security Policy

International Journal of Conflict and Violence, 2022
The scientific goal of this paper is to conceptualize the phenomenon of ‘strategic exploitation’ of Kurdish political entities and to investigate it as a process that triggered the change in Kurdish actorness from isolated non-state to de facto state ...
Piotr Sosnowski
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Custom and Path Dependence in Economics

, 2023
This paper deals with the role of customs in economics. With few excep-tions, economists reserved scarce interest to this topic. Some classical authors counter-posed custom to market competition, by considering the former as limiting develop-ment and the latter as progressing it.
openaire   +2 more sources

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source