Results 41 to 50 of about 1,067,624 (281)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Path integral measure for first order and metric gravities

, 2003
The equivalence between the path integrals for first order gravity and the standard torsion-free, metric gravity in 3+1 dimensions is analyzed. Starting with the path integral for first order gravity, the correct measure for the path integral of the ...
Aros, Rodrigo, Contreras, Mauricio, Zanelli, Jorge   +2 more
core   +1 more source

Self-Normalizing Path Integrals

Foundations of Physics
The normalization in the path integral approach to quantum field theory, in contrast with statistical field theory, can contain physical information. The main claim of this paper is that the inner product on the space of field configurations, one of the fundamental pieces of data required to be added to quantize a classical field theory, determines the
Ivan M. Burbano, Francisco Calderón
openaire   +2 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The Path Integral for a Particle in Curved Spaces and Weyl Anomalies

, 1991
The computation of anomalies in quantum field theory may be carried out by evaluating path integral Jacobians, as first shown by Fujikawa. The evaluation of these Jacobians can be cast in the form of a quantum mechanical problem, whose solution has a ...
Abers, Adler, Alvarez-Gaumé, Alvarez-Gaumé, Alvarez-Gaumé, Bardeen, Bastianelli, Bell, Capper, De Witt, De Witt, De Witt, Dekker, Diaz, Feynman, Feynman, Feynman, Fiorenzo Bastianelli, Friedan, Fujikawa, Fujikawa, Fujikawa, Hatsuda, Howe, Schulman, Schwinger   +25 more
core   +1 more source

Geometry and complexity of path integrals in inhomogeneous CFTs

Journal of High Energy Physics, 2021
In this work we develop the path integral optimization in a class of inhomogeneous 2d CFTs constructed by putting an ordinary CFT on a space with a position dependent metric.
Paweł Caputa, Ian MacCormack
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Jackiw-Teitelboim gravity in the second order formalism

Journal of High Energy Physics, 2021
We formulate the path integral for Jackiw-Teitelboim gravity in the second order formalism working directly with the metric and the dilaton. We consider the theory both in Anti-de Sitter(AdS) and de Sitter space(dS) and analyze the path integral for the ...
Upamanyu Moitra, Sunil Kumar Sake, Sandip P. Trivedi   +2 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source