Results 201 to 210 of about 203,756 (262)

Clinical Utility and Therapeutic Strategy Value of Metagenomic Next-Generation Sequencing in Pulmonary Infection Among Cancer Patients. [PDF]

Infect Drug Resist
Cao Y, Huang J, Wu W, Xu Z, Wang C, Wu X, Zhan C, Xing J, Liu J, Zhu M, Ma S.   +10 more
europepmc   +1 more source

A Novel Function of Nonadecanoic Acid in Regulating Glucose Homeostasis

Advanced Science, EarlyView.
This study identifies the odd‐chain fatty acid C19:0 as an endogenous ligand of GPR120 that promotes glucose homeostasis via Gαq signaling. In obesity, elevated palmitic acid suppresses endogenous C19:0 production through a miRNA–PPARα–HACL1 pathway, offering a promising direction for understanding the role of OCFAs in human health.
Yanting Hou, Yinghua Ma, Qin Liu, Dingling Ma, Yuxin Tong, Lili Xu, Xiaolong Chu, Jingzhou Wang, Maodi Liang, Mengyuan Zhao, Huizi Zhang, Yurui Su, Jianxin Xie, Cuizhe Wang, Jun Zhang   +14 more
wiley   +1 more source

Pathogen landscape and synergistic interactions in pediatric ARIs: implications for broad-spectrum surveillance via targeted NGS. [PDF]

Microbiol Spectr
Zhou J, Li T, Yuan S, Wang Y, Zhao A, He Y, Zhan X, Wu B, Jia Z, Liu Y, Li J, Yang H, Zhou J, Wang Z, Huang J.   +14 more
europepmc   +1 more source

Testicular mRNA‐LNP Delivery: A Novel Therapy for Genetic Spermatogenic Disorders

Advanced Science, EarlyView.
In the current study, we developed a novel therapy for genetic spermatogenic disorders. It was revealed that in vivo delivery of mRNA LNP3 could restore spermatogenesis in Msh5D486Y/D486Y and Maps KO mouse models with meiotic arrest. Notably, the offspring without genomic integration was born using ICSI derived from the rescue of Msh5D486Y/D486Y mouse ...
Chenwang Zhang, Nan Liang, Wenbo Li, Shuai Xu, Peng Li, Wanze Ni, Na Li, Sha Han, Ningjing Ou, Haowei Bai, Yuxiang Zhang, Furong Bai, Yifan Sun, Dewei Qian, Xinjie Bu, Erlei Zhi, Ruhui Tian, Yuhua Huang, Jingpeng Zhao, Fujun Zhao, Hao Chen, Zheng Li, Chencheng Yao   +22 more
wiley   +1 more source

Microbial characteristics and risk factors in PICU with freshwater drowning-associated pneumonia. [PDF]

Eur J Pediatr
Zhang N, Zhang X, Guo Y, Zheng Y, Gai W, Zhu B, Yang Z.   +6 more
europepmc   +1 more source

Global distribution and evolution of nine major non-polio enteroviruses revealed by genomic data mining. [PDF]

Biochem Biophys Rep
Mo H, Li H, Wu J, Yi L, He F, Huang Q, Zhang X, Yang Q, Chen T, Zhou X.   +9 more
europepmc   +1 more source

Evolving Aerobic Bacterial Skin Flora and Healthcare-Associated Infections Among Intensive Care Unit Patients at a Tertiary Care Hospital: A Therapeutic Concern. [PDF]

Cureus
Gupta U, Kapoor G, Kaur R, Patbamniya N, Nayak D, Darshan H, Tiwari A.   +6 more
europepmc   +1 more source

Agnostic capture of pathogens for the detection and diagnostics of emerging threats. [PDF]

iScience
Sakkos A, Saint-John B, Tyml T, Myskova E, Aureli L, Inman JL, Snijders AM, Mouncey NJ, Mukundan H, Schulz F.   +9 more
europepmc   +1 more source

Anti-Shigella activity and killing kinetics of compounds from MMV Pathogen and COVID Boxes: Identifying leads against Shigellosis. [PDF]

Curr Res Pharmacol Drug Discov
Tchokouaha Yamthe LR, Kengne Mediesse F, Melogmo Dongmo YK, Matchuenkam Gayap SR, Dize D, Tsouh Fokou PV, Boyom FF.   +6 more
europepmc   +1 more source