Results 31 to 40 of about 203,756 (262)

Nine-Year Analysis of Isolated Pathogens and Antibiotic Susceptibilities of Infectious Endophthalmitis from a Large Referral Eye Center in Southern China

Infection and Drug Resistance, 2020
Lixia Lin,* Feng Mei,* Jingyu Liao, Yao Yang, Fang Duan, Xiaofeng Lin Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, People’s Republic of China*These authors contributed equally to this ...
Lin L, Mei F, Liao J, Yang Y, Duan F, Lin X   +5 more
doaj  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Designing Probiotic Therapies With Broad-Spectrum Activity Against a Wildlife Pathogen

Frontiers in Microbiology, 2020
Host-associated microbes form an important component of immunity that protect against infection by pathogens. Treating wild individuals with these protective microbes, known as probiotics, can reduce rates of infection and disease in both wild and ...
Xavier A. Harrison, Xavier A. Harrison, Thomas Sewell, Matthew Fisher, Rachael E. Antwis   +4 more
doaj   +1 more source

Study on pathogen spectrum of 1,046 hospitalized children with respiratory tract infections during COVID-19

Journal of Laboratory Medicine, 2023
This study aimed to describe the pathogen spectrum of bacteria and viruses of RTIs in hospitalized children during the Coronavirus disease 2019 (COVID-19) epidemic in Shenzhen.
Han Xin-Yuan, Wang Xue-Ling, Zhang Jin, Gong Xue-Lei, Kan Li-Juan, Wei Jie-Hong, Zhang Xiu-Ming   +6 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

The application prospect of metagenomic next-generation sequencing technology in diagnosing suspected lower respiratory tract infections

Frontiers in Cellular and Infection Microbiology
ObjectiveLower respiratory tract infections present substantial diagnostic and therapeutic challenges, negatively impacting individual health. This study aims to utilize metagenomic next-generation sequencing (mNGS) technology to comprehensively explore ...
Wei Li, Mingming Zhao, Weiwei Wu, Gang Chen, Yanping Hang, Haixia Zheng, Zhenyun Gao, Jia Liu, Yuguo Zhao   +8 more
doaj   +1 more source

Spectrum of pathogen- and model-specific histopathologies in mouse models of acute pneumonia. [PDF]

PLoS ONE, 2017
Pneumonia may be caused by a wide range of pathogens and is considered the most common infectious cause of death in humans. Murine acute lung infection models mirror human pathologies in many aspects and contribute to our understanding of the disease and
Kristina Dietert, Birgitt Gutbier, Sandra M Wienhold, Katrin Reppe, Xiaohui Jiang, Ling Yao, Catherine Chaput, Jan Naujoks, Markus Brack, Alexandra Kupke, Christin Peteranderl, Stephan Becker, Carolin von Lachner, Nelli Baal, Hortense Slevogt, Andreas C Hocke, Martin Witzenrath, Bastian Opitz, Susanne Herold, Holger Hackstein, Leif E Sander, Norbert Suttorp, Achim D Gruber   +22 more
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

The spectrum of pathogens in combat wounds of the limbs: own results and retrospective analysis

Travmatologiâ i Ortopediâ Rossii
Background. Infectious complications arising from combat wounds are one of the most serious problems in military medicine. Their microbiological monitoring is a necessary foundation for choosing the initial antimicrobial treatment, predictive risk ...
Rashid A. Shafigulin, Albina A. Zvegintseva, Ildar F. Akhtyamov, Alexey L. Emelin, Eler B. Mirazimov, Nikita V. Kharin, Inna R. Valiullina   +6 more
doaj   +1 more source

Evaluation of PCR based assays for the improvement of proportion estimation of bacterial and viral pathogens in diarrheal surveillance

Frontiers in Microbiology, 2016
Diarrhea can be caused by a variety of bacterial, viral and parasitic organisms. Laboratory diagnosis is essential in the pathogen-specific burden assessment. In the pathogen spectrum monitoring in the diarrheal surveillance, culture methods are commonly
Hongxia eGuan, Jingyun eZhang, Jingyun eZhang, Yong eXiao, Dan eSha, Xia eLing, Biao eKan, Biao eKan   +7 more
doaj   +1 more source