Results 51 to 60 of about 203,756 (262)

Extended spectrum beta lactamase producing Proteus penneri: A rare missed pathogen?

Indian Journal of Pathology and Microbiology, 2014
Indole negative Proteus species are invariably incorrectly identified as Proteus mirabilis, often missing out isolates of Proteus penneri. We report a case of extended spectrum beta lactamase producing and multidrug-resistant P. penneri isolated from pus
Anita Pandey, Himani Verma, Ashish K Asthana, Molly Madan   +3 more
doaj   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Impact of the launch of EV71 vaccination on prevalence characteristics and pathogen spectrum of severe hand, foot and mouth disease in Henan province, 2014 – 2020: a register data analysis

Zhongguo gonggong weisheng
Objective To explore changes in prevalence characteristics and pathogen spectrum of severe hand, foot and mouth disease (HFMD) in Henan province before and after launching vaccination of enterovirus 71 (EV71) vaccine for developing strategies on HFMD ...
Ruolin WANG, Yafei LI, Wenhua WANG, Haiyan WEI, Shidong LU, Haifeng WANG, Ying YE, Xueyong HUANG   +7 more
doaj   +1 more source

Microbiological pathogen analysis in native versus periprosthetic joint infections: a retrospective study

Journal of Orthopaedic Surgery and Research, 2022
Background The presence or absence of an implant has a major impact on the type of joint infection therapy. Thus, the aim of this study was the examination of potential differences in the spectrum of pathogens in patients with periprosthetic joint ...
Sebastian Linke, Alexander Thürmer, Kevin Bienger, Christian Kleber, Petri Bellova, Jörg Lützner, Maik Stiehler   +6 more
doaj   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Clinical pathogen profiles and lung microbiome features in lung infection patients and concurrent cancer: insights from metagenomics next-generation sequencing

Open Life Sciences
Pulmonary infections in immunocompromised cancer patients present significant diagnostic and therapeutic challenges. From Dec 2021 to Aug 2023, 85 patients with pulmonary infection were enrolled and categorized into a cancer group (CP, n = 20) and a non ...
Liu Dandan, Ma Yuehong, Ma Qian, Huang Huihua, Li Tianyu, Wang Jin, Zhang Jin, Cheng Xuesong, Ge Xueru, Chen Yan, Zhang Yanbei   +10 more
doaj   +1 more source

Fluid and Neuroimaging Biomarkers in Microgliopathy Colony‐Stimulating Factor‐1 Receptor‐Related Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela, Madison Reeves, Karen Jansen‐West, Judith Dunmore, Yuping Song, Audrey Strongosky, Sunil Gandhi, Gilana Pikover, Matt Blurton‐Jones, Robert C. Spitale, Erik H. Middlebrooks, Leonard Petrucelli, Mercedes Prudencio, Zbigniew K. Wszolek   +13 more
wiley   +1 more source

Epidemiological characteristics and antimicrobial resistance of pathogens isolated from blood cultures in southern Jiangxi, China, 2020–2024

Frontiers in Cellular and Infection Microbiology
ObjectiveThis study aimed to analyze the distribution characteristics and dynamic trends of antimicrobial resistance among pathogens isolated from blood cultures of adult patients at a large tertiary hospital in southern Jiangxi Province, China, from ...
Zhengting Liu, Liqin Zhang, Jian Zou
doaj   +1 more source

Mutational Spectrum Analysis of Neurodegenerative Diseases and Its Pathogenic Implication [PDF]

International Journal of Molecular Sciences, 2015
One of the most conspicuous features of neurodegenerative diseases (NDs) is the occurrence of dramatic conformation change of individual proteins. We performed a mutational spectrum analysis of disease-causing missense mutations in seven types of NDs at nucleotide and amino acid levels, and compared the results with those of non-NDs.
Shen, Liang, Ji, Hong-Fang
openaire   +2 more sources

Olink Proteomics Analysis Reveals Heterogeneous Responses to FcRn Blockade in Anti‐AChR Antibody‐Positive Myasthenia Gravis: FGF‐19 as a Novel Biomarker

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to systematically observe the clinical manifestations, immune cell subsets, and dynamic changes in serological indicators in patients with myasthenia gravis (MG) before and after efgartigimod (EFG) treatment. Methods We analyzed the baseline data, laboratory parameters, and lymphocyte subset proportions in MG ...
Tiancheng Luo, Deyou Peng, Zhouao Zhang, Mingjin Yang, Xinyan Guo, Tianyu Ma, Xiaoyu Huang, Mingming Xu, Linlin Fu, Yong Zhang   +9 more
wiley   +1 more source