Results 201 to 210 of about 1,317,903 (246)

Targeting the PGRN‐BMP Lysosomal Axis With NPs@PGRN Reverses Immunometabolic Dysfunction in Chronic Septic Arthritis

Advanced Science, EarlyView.
Chronic septic arthritis involves intracellular bacterial persistence and lipid‐immune crosstalk via the PGRN‐BMP lysosomal axis. A dual‐targeting nanoparticle system (NPs@PGRN) restores lysosomal bactericidal function, reduces bacterial burden, and reprograms macrophage immunity, offering a novel therapeutic strategy. ABSTRACT Chronic septic arthritis,
Congsun Li, Jiaqi Fan, Tao Sun, Wushi Cui, Jiaxuan Zou, Weinan Yang, Liang Chen, Jian Xiao, Shicheng Wang, Tao Zhang, Jianqiao Hong, An Liu, Haobo Wu   +12 more
wiley   +1 more source

Time‐Resolved SAXS Reveals Distinct Millisecond Metal‐Induced Conformational Dynamics of Monomeric α‐Synuclein

Advanced Science, EarlyView.
Time‐resolved SAXS reveals how physiologically relevant metal ions shape the earliest conformational responses of monomeric α‐synuclein. Fe3+ induces rapid compaction, Cu2+ generates heterogeneous and partially folded ensembles, while Mn2+ and Zn2+ cause only modest changes.
Rebecca Sternke‐Hoffmann, Miriam Dos Santos Pinto, Xue Wang, Jinghui Luo   +3 more
wiley   +1 more source

Succinylation: A novel regulatory axis in cholelithiasis-insights from lysine acetyltransferase 2A/adenosine monophosphate-activated protein kinase signaling. [PDF]

World J Gastroenterol
Wei HR, Xiao F.
europepmc   +1 more source

Exploration of pathogenesis and targeted drugs of postmenopausal osteoporosis by means of analysis based on reverse network pharmacology. [PDF]

Medicine (Baltimore)
Wu D, Zhao W, Ni Y.
europepmc   +1 more source

Identification of SDC1 as a Key Regulator and Therapeutic Target in Rheumatoid Arthritis via JAK2-STAT3 Pathway. [PDF]

Int J Rheum Dis
Cao G, Wu Z, Du Y, Dai D, Sun Y, Jia X, Cai H.   +6 more
europepmc   +1 more source

Immune Cells at the Frontline of SFTSV Infection. [PDF]

J Microbiol Biotechnol
Park S, Kim C.
europepmc   +1 more source

The Emerging Roles of GlycoRNAs in the Pathogenesis of Sepsis. [PDF]

Cells
Li X, Nallajennugari S, Fu J, Faisal A, Fu M.   +4 more
europepmc   +1 more source

Evaluation of chemerin levels in the pathogenesis of psoriasis. [PDF]

Front Med (Lausanne)
Matwiejuk M, Kulczyńska-Przybik A, Łukaszuk B, Myśliwiec H, Myśliwiec P, Chabowski A, Mroczko B, Flisiak I.   +7 more
europepmc   +1 more source