Results 81 to 90 of about 1,118,385 (256)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Great diverse rhizobial community nodulating Astragalus mongholicus in the northeastern region of China

Frontiers in Microbiology
IntroductionAstragalus mongholicus Bunge is an important medicinal legume species widely cultivated in northeastern China (NEC) and northwestern China (NWC) and can establish a symbiotic relationship with nitrogen-fixing rhizobial strains. However, there
Mengzhe Gao, Xiaoxia Yuan, Xiaoxia Yuan, Zhaojun Ji, Zhaojun Ji, Zhaojun Ji, Bingjie Yang, Hua Li, Hua Li, Bo Zhang, Bo Zhang   +10 more
doaj   +1 more source

Synthetic Peptides against Plant Pathogenic Bacteria

Microorganisms, 2022
The control of plant diseases caused by bacteria that seriously compromise crop productivity around the world is still one of the most important challenges in food security.
Esther Badosa, Marta Planas, Lidia Feliu, Laura Montesinos, Anna Bonaterra, Emilio Montesinos   +5 more
doaj   +1 more source

Exoribonucleases as Modulators of Virulence in Pathogenic Bacteria [PDF]

Frontiers in Cellular and Infection Microbiology, 2012
Pathogenic bacteria are responsible for severe diseases worldwide. RNA stability is a major player controlling the expression of virulence factors. Ribonucleases (RNases) are the enzymes responsible for the maturation and degradation of RNA molecules (Arraiano et al., 2010; Silva et al., 2011).
Matos, Rute G., Bárria, Cátia, Pobre, Vânia, Andrade, José M., Arraiano, Cecília M.   +4 more
openaire   +3 more sources

Distribution and Drug Resistance of Pathogenic Bacteria and Prognosis in Patients with Septicemia Bloodstream Infection with Renal Insufficiency

, 2022
Deng Pan,1,* Pin Peng,2,* Yu Fang,3 Jun Lu,3 Minghao Fang3 1Department of Infectious Disease, Xianning Central Hospital, The First Affiliated Hospital of Hubei University of Science and Technology, Xianning, Hubei, People’s Republic of China ...
Fang Y, Pan D, Lu J, Peng P, Fang M
core  

Fate of the H-NS-repressed bgl operon in evolution of Escherichia coli. [PDF]

, 2009
In the enterobacterial species Escherichia coli and Salmonella enterica, expression of horizontally acquired genes with a higher than average AT content is repressed by the nucleoid-associated protein H-NS.
T Sabari Sankar, Plum, Georg, Vartul Sangal, Schnetz, K., T. Sabari Sankar, Mark Achtman, Neelakanta, Girish, Sangal, Vartul, Achtman, Mark, Karin Schnetz, Sankar, T. Sabari, Sankar, T., Schnetz, Karin, Sangal, V., Plum, G., Neelakanta, G., Achtman, M., Georg Plum, Girish Neelakanta   +18 more
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Real-time PCR-based Detection of Foodborne Pathogen Cronobacter sakazakii DNA in Infant Formula Milk with Specific Targeting on the hfq Gene

Hayati Journal of Biosciences
Cronobacter sakazakii has been linked to cause meningitis, necrotizing enterocolitis, and sepsis in infants and newborns, with case fatality rates ranging from 40 to 80%.
Muktiningsih Nurjayadi, Dandy Akbar Juliansyah, Jefferson Lynford Declan, Gladys Indira Putri, Ismaya Krisdawati, Atikah Nur Rahmawati, Maharanianska Azzahra, Irvan Maulana, Gusti Angieta Putri, Fera Kurniadewi, Irma Ratna Kartika, Vira Saamia, I Made Wiranatha, Bassam Abomoelak, Hesham Ali El-Enshasy   +14 more
doaj   +1 more source

Isolation and Identification of Pathogenic Bacteria Showing Resistance against Disinfectants

Journal of Pure and Applied Microbiology, 2019
Successive use and misuse of disinfectant against certain microbes may trigger resistance, causing the problem of ineffectiveness of disinfectant due to development of resistance strains.
Bassam Oudh Al-johny, Abdulelah M. Alkhuzaee   +1 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source