Results 71 to 80 of about 346,058 (305)

Standardization of Distribution of Work Clothing, Footwear and Personal Protective Equipment among Employees Working with Infectious Disease Agents

Проблемы особо опасных инфекций
When working with infectious disease agents, personal protective equipment (PPE) is widely used, which is one of the significant elements of ensuring biological safety.
T. A. Kostyukova, M. V. Gordeeva, M. N. Lyapin, Z. L. Devdariani, S. P. Zadnova   +4 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

The US Statement at the Fifth Review Conference: Compounding the Error in Rejecting the Composite Protocol [PDF]

, 2002
Ye
Dando, Malcolm R., Pearson, Graham S., Sims, N.A.   +2 more
core  

Fungal Pathogens Infecting Soybean Aphid and Aphids on Other Crops Grown in Soybean Production Areas of Michigan [PDF]

, 2018
Seasonal prevalence of fungal pathogens infecting soybean aphid, Aphis glycines Matsumura (Hemiptera: Aphididae), was assessed from 2004 to 2006 in two Michigan soybean production areas. In 2005 and 2006 field-collected soybean aphids were incubated, and
Brewer, Michael J, Noma, Takuji
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Provision of Biological Safety in the Territory of the Republic of Tatarstan during Preparation and Holding of FIFA World Cup-2018 in Kazan

Проблемы особо опасных инфекций, 2019
Objective – assessment of effectiveness of the measures for biological safety provision at potentially hazardous facilities in the territory of the Republic of Tatarstan in the process of preparation and holding of FIFA World Cup-2018 in Kazan. Materials
M. A. Patyashina, M. V. Trofimova, L. G. Avdonina, L. T. Garaeva, G. R. Mansurova   +4 more
doaj   +1 more source

Use of Non-Pathogenic Biological Agents as Biological Warfare Simulants for the Development of a Stand-Off Detection System [PDF]

Journal of Microbial & Biochemical Technology, 2014
Development of new technologies for Biological Warfare Agents (BWA) stand-off detection implies several safeties, logistic and economic drawbacks that involve production of different highly virulent bacteria and viruses, their isolation and characterization under adequate bio-containment and sample preparation for each agent to evaluate the testing ...
CENCIARELLI, ORLANDO, Pietropaoli, S, Gabbarini, V, Carestia, M, D’Amico, F, MALIZIA, ANDREA, GELFUSA, MICHELA, PIZZOFERRATO, ROBERTO, Sassolini, A, Di Giovanni, D, Orecchio, Francesca M, PALOMBI, LEONARDO, Bellecci, C, GAUDIO, PASQUALINO   +13 more
openaire   +4 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Application of Risk Assessment Methodology for Substantiation of Measures Complex on Provision of Safe Functioning of Mobile Laboratories of Specialized Anti-Epidemic Teams

Проблемы особо опасных инфекций, 2011
A set of risk assessment methods was used for substantiation of safe functioning of mobile laboratories (ML) of specialized anti-epidemic teams (SAET). The utilized methods were borrowed from diverse spheres of activity and recommended for evaluation of ...
M. V. Pchelintseva, M. N. Lyapin, I. N. Ezhov, A. V. Toporkov   +3 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source