Results 51 to 60 of about 1,414,665 (306)

Correction: Bacterial immune evasion through manipulation of host inhibitory immune signaling. [PDF]

PLoS Pathogens, 2015
[This corrects the article DOI: 10.1371/journal.ppat.1004644.].
PLOS Pathogens Staff
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Correction: The RhoGAP SPIN6 associates with SPL11 and OsRac1 and negatively regulates programmed cell death and innate immunity in rice. [PDF]

PLoS Pathogens, 2015
[This corrects the article DOI: 10.1371/journal.ppat.1004629.].
PLOS Pathogens Staff
doaj   +1 more source

Concentrations of Acute-Phase Proteins in Milk from Cows with Clinical Mastitis Caused by Different Pathogens

, 2020
Among the new diagnostic methods for mastitis detection under development, milk acute-phase proteins (APPs) are receiving special attention. The study aimed to compare the profile of milk APPs from cows with natural clinical mastitis caused by distinct ...
Langoni, Hélio, Schmidt, Elizabeth M. S. [UNESP], Joaquim, Sâmea F. [UNESP], Cerri, Ronaldo L. A., Bruna C. Lopes, Dalanezi, Felipe M. [UNESP], Christopher Chadwick, Elizabeth M. S. Schmidt, Guimarães, Felipe F. [UNESP], Langoni, Hélio [UNESP], Chadwick, Christopher, Hélio Langoni, Sâmea F. Joaquim, Felipe M. Dalanezi, Ronaldo L. A. Cerri, Simoni T. Guerra, Felipe F. Guimarães, Guerra, Simoni T. [UNESP], Lopes, Bruna C. [UNESP], Joaquim, Sâmea F., Guerra, Simoni T., Lopes, Bruna C., Schmidt, Elizabeth M. S., Guimarães, Felipe F., Dalanezi, Felipe M.   +24 more
core   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Integrated dataset of screening hits against multiple neglected disease pathogens. [PDF]

, 2011
New chemical entities are desperately needed that overcome the limitations of existing drugs for neglected diseases. Screening a diverse library of 10,000 drug-like compounds against 7 neglected disease pathogens resulted in an integrated dataset of 744 ...
Clive Yeates, Mansour Nuha R., Ridley, Robert, Simon Townson, Dominique Besson, Yeates, Clive, Townson, Simon, Yeates Clive, Jean-Marc Paris, Geary Timothy, Murthy P. K., Ramirez, Bernadette, Maes, Louis, Ramirez Bernadette, Yousif Fouad, Solomon Nwaka, Van Voorhis Wesley C., Samje, Moses, An Matheeussen, Murthy, PK, Suzanne Gokool, Cho-Ngwa Fidelis, P K Murthy, Timothy Geary, Bickle Quentin, Gokool, Suzanne, Bernadette Ramirez, Fidelis Cho-Ngwa, Geary, Timothy, Paris, Jean-Marc, Paris Jean-Marc, Quentin Bickle, Fakorede, Foluke, Shailja Misra-Bhattacharya, Samje Moses, Moses Samje, Bickle, Quentin, Besson, Dominique, Fouad Yousif, Gokool Suzanne, Louis Maes, Van Voorhis, Wesley C, Yousif, Fouad, Nwaka, Solomon, Maes Louis, Townson Simon, Nwaka Solomon, Wesley C Van Voorhis, Misra-Bhattacharya, Shailja, Ridley Robert, Cho-Ngwa, Fidelis, Robert Ridley, Matheeussen An, Fakorede Foluke, Besson Dominique, Matheeussen, An, Foluke Fakorede, Nuha R Mansour, Mansour, Nuha R, Misra-Bhattacharya Shailja, et al.   +60 more
core   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Correction: A Large Collection of Novel Nematode-Infecting Microsporidia and Their Diverse Interactions with Caenorhabditis elegans and Other Related Nematodes. [PDF]

PLoS Pathogens, 2017
[This corrects the article DOI: 10.1371/journal.ppat.1006093.].
PLOS Pathogens Staff
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source