Results 241 to 250 of about 840,940 (292)

Echocardiography in Athletes: the Ever-Evolving Assessment of Physiology Versus Pathology. [PDF]

Curr Cardiol Rep
Fritzlen JT, Martinez MW.
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Bridging the skill gap in breast ultrasound: a PDCA management for standardized reporting and accurate BI-RADS categorization in postgraduate medical education. [PDF]

BMC Med Educ
Liu C, Xue H, Bai M, Zhao B, Cui L, Jiang J.   +5 more
europepmc   +1 more source

Psychopathic Personality [PDF]

, 1937
Sheehan, Robert F.
core   +1 more source

Clinical and pathological features of an Alzheimer's disease patient with the MAPT ΔK280 mutation

, 2007
Parastoo Momeni, Alan Pittman, Tammaryn Lashley, Jana Vandrovcová, Elke Malzer, Connie Luk, Christine Hulette, Andrew J. Lees, Tamás Révész, John Hardy, Rohan de Silva   +10 more
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

The Prognostic Value of Lymph Node Downstaging Following Neoadjuvant Chemoimmunotherapy for Non-Small Cell Lung Cancer. [PDF]

J Cancer
Guo M, Abdel-Rasoul M, Chang J, Guo A, Baiu I, D'Souza DM, Merritt RE, Kneuertz PJ.   +7 more
europepmc   +1 more source

Role of Endothelial Nox4 in Retinal Vascular Development and Pathological Angiogenesis

, 2017
Xixiang Tang, Joshua Jianxin Wang, Sarah Xin Zhang   +2 more
openalex   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Acute Spinal Cord Injury in the Setting of C6 Pathologic Fracture Secondary to Metastatic Paraganglioma: A Case Report and Review of Literature. [PDF]

Cureus
Kaur A, Danehower S, Rupp HG, Hamidi R, Bezerra Gondim MJ, Altstadt T.   +5 more
europepmc   +1 more source