Results 241 to 250 of about 502,160 (304)

Safety and pathologic response of neoadjuvant pulsed electric field ablation and systemic therapy in early-stage resectable lung cancer: case series. [PDF]

J Thorac Dis
Reisenauer JS, DiBardino DM, Criner GJ, Hunt SJ, Panaro J, Friedberg J, Mansfield AS, Aggarwal C, Bodor JN, Callstrom MR.   +9 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Outcomes of Percutaneous Stabilization for Pelvic Metastatic Bone Disease: A Systematic Review and Meta-Analysis. [PDF]

Cancers (Basel)
Federico AA, Carter ZA, Iwasyk AW, Elmi Assadzadeh G, Monument MJ, Cable MG, Kendal JK.   +6 more
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Tumor Mutational Burden and Clinical Outcomes in Patients with Muscle-Invasive Bladder Cancer Treated with Neoadjuvant Chemotherapy. [PDF]

Cancer Res Commun
Burgess EF, Brown LC, McCormack M, Liu L, Steuerwald N, Stoen E, Ciampricotti M, Doherty PM, Williams E, Clark PE, Zhang W, Symanowski JT.   +11 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Concordance of pathologic response assessment between local and central review in melanoma: a post hoc analysis of KEYMAKER-U02 substudy 02C. [PDF]

ESMO Open
Tetzlaff M, Taube JM, Long GV, Dummer R, Robert C, Menzies AM, Hill A, Gaudy-Marqueste C, Portnoy DC, Lebbe C, Krishnan R, Xu J, Fukunaga-Kalabis M, Krepler C, Scolyer RA.   +14 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Carinal Squamous Cell Carcinoma Causing Progressive Central Airway Obstruction: CT, FDG PET/CT, Bronchoscopic Pre- and Post-Debulking, and Pathologic Correlation. [PDF]

Case Rep Radiol
Dhakal S, Adhikari G, Kanj Ahmad A.
europepmc   +1 more source

Use of the IlluminOss Photodynamic Bone Stabilisation System Following Stereotactic Body Radiation Therapy for Limb-Sparing in Six Dogs With Presumptive Appendicular Osteosarcoma. [PDF]

Vet Comp Oncol
Pope EA, Wavreille VA, Lapsley JL, Green EM, Kisseberth WC, Rabiner R, Selmic LE.   +6 more
europepmc   +1 more source