Results 81 to 90 of about 1,052,442 (336)

Hexokinase‐2 as a Therapeutic Target: Alleviating Herpes Simplex Keratitis Through Metabolic Reprogramming

Advanced Science, EarlyView.
Herpes Simplex Virus Type 1 (HSV‐1) infection triggers metabolic reprogramming in corneal cells, shifting from mitochondrial respiration to aerobic glycolysis with marked upregulation of Hexokinase‐2 (HK2). This study identifies HK2 as a therapeutic target: inhibiting HK2 with lonidamine significantly reduces viral replication and promotes corneal ...
Dan Jiang, Yining Sun, Xintong Yu, Ruoqi Wang, Yuting Zhang, Jinjie Yu, Shuang Xie, Yujia Cai, Yuhong Luo, Wei Chen   +9 more
wiley   +1 more source

Eye shape and retinal shape, and their relation to peripheral refraction [PDF]

, 2012
Purpose: We provide an account of the relationships between eye shape, retinal shape and peripheral refraction. Recent findings: We discuss how eye and retinal shapes may be described as conicoids, and we describe an axis and section reference system for
Atchison, David, Mallen, Edward, Mathur, Ankit, Pope, James, Verkicharla, Pavan   +4 more
core   +2 more sources

Morphological characteristics of retinal vessels in eyes with high myopia: Ultra-wide field images analyzed by artificial intelligence using a transfer learning system

Frontiers in Medicine, 2023
PurposeThe purpose of this study is to investigate the retinal vascular morphological characteristics in high myopia patients of different severity.Methods317 eyes of high myopia patients and 104 eyes of healthy control subjects were included in this ...
Jianbo Mao, Jianbo Mao, Xinyi Deng, Xinyi Deng, Yu Ye, Hui Liu, Yuyan Fang, Zhengxi Zhang, Nuo Chen, Mingzhai Sun, Lijun Shen, Lijun Shen   +11 more
doaj   +1 more source

Quantitative assessment of the long-term effect of photodynamic therapy in patients with pathologic myopia [PDF]

, 2018
Background: In patients with classic subfoveal choroidal neovascularization (CNV) secondary to pathologic myopia (PM), photodynamic therapy (PDT) has been shown to stabilize the visual acuity.
Jochmann, Claudia, Schnurrbusch, Ute, Wiedemann, Peter, Wolf, Sebastian   +3 more
core  

Microscopic Inner Retinal Hyper-reflective Phenotypes in Retinal and Neurologic Disease [PDF]

, 2014
Purpose. We surveyed inner retinal microscopic features in retinal and neurologic disease using a reflectance confocal adaptive optics scanning light ophthalmoscope (AOSLO). Methods. Inner retinal images from 101 subjects affected by one of 38 retinal or
Carroll, Joseph, Cooper, Robert F., Dubis, Adam M., Dubra, Alfredo, Higgins, Brian P., Kim, Judy E., Scoles, Drew, Stepien, Kimberly E., Summerfelt, Phyllis, Weinberg, David V.   +9 more
core   +2 more sources

Mainstream Artificial Intelligence Technologies in Contemporary Ophthalmology

Advanced Intelligent Systems, EarlyView.
This review explores the latest artificial intelligence (AI) technologies in ophthalmology, focusing on four key data types: medical imaging, electronic health records, robotic‐assisted surgery, and genomics. It examines the structural features, use cases, clinical goals, and evaluation metrics of various AI algorithms, while also introducing emerging ...
Shiqi Yin, Lei Wang, Shanjun Wu, Jiewei Jiang, Wei Qiang, Yangyang Wang, Shihong Wang, Yi Shao, Wei Chen, Zhongwen Li   +9 more
wiley   +1 more source

Machine Learning Approaches in High Myopia: Systematic Review and Meta-Analysis

Journal of Medical Internet Research
BackgroundIn recent years, with the rapid development of machine learning (ML), it has gained widespread attention from researchers in clinical practice.
Huiyi Zuo, Baoyu Huang, Jian He, Liying Fang, Minli Huang   +4 more
doaj   +1 more source

Relative peripheral refraction across 4 meridians after orthokeratology and LASIK surgery [PDF]

, 2018
Background: To characterize the axial and off-axis refraction across four meridians of the retina in myopic eyes before and after Orthokeratology (OK) and LASIK surgery. Methods: Sixty right eyes with a spherical equivalent (M) between − 0.75 to − 5.25
González-Méijome, José Manuel, Lopes-Ferreira, Daniela, Queirós, A., Ramón Gutiérrez, Ángel, Sousa, Ana Amorim de, Villa-Collar, César   +5 more
core   +2 more sources

Phenotypical and Genotypical Expansion of Autosomal‐Dominant KDM1A‐Related Neurodevelopmental Disorder Spectrum: A Case Report

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT KDM1A‐related neurodevelopmental disorder (CPRF, OMIM #616728) is characterized by cleft palate, global developmental delay, and distinct facial gestalt, but phenotypic knowledge of this ultra‐rare autosomal dominant disorder is limited. Here, we report on a 13‐year‐old boy with a novel heterozygous, likely pathogenic germline missense variant
Sebastian Burkart, Melanie Spanjaard, Lilian Kaufmann, Katrin Hinderhofer, Christian P. Schaaf, Markus Ries, Maja Hempel   +6 more
wiley   +1 more source

Two years follow-up outcome of verteporfin therapy for subfoveal choroidal neovascularization in pathologic myopia in Indian eyes

Indian Journal of Ophthalmology, 2008
Context: In India, refractive errors are a major cause of treatable blindness. Population surveys in southern India have shown prevalence of high myopia to be 4.32-4.54%. Photodynamic therapy (PDT) for choroidal neovascularization (CNV) caused by
Hussain Nazimul, Khanna Rohit, Das Taraprasad, Narayanan Raja, Sunday Oluleye, Bansal Azad, Reddy Rajeev   +6 more
doaj