Results 191 to 200 of about 2,815,174 (287)

Long‐term culture of skin biopsies: maintenance of fibroblast production and competency of reprogramming

FEBS Open Bio, EarlyView.
Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar, Michael A. Ripperger, Grant M. Westlake, Kevin C. Ess   +3 more
wiley   +1 more source

Disease-associated adipose browning: current evidence and perspectives. [PDF]

Adipocyte
Zhang X, Han X, Xu J, Li G.
europepmc   +1 more source

A Case of an Invasive Lobular Carcinoma with Extracellular Mucin: Radio-Pathological Correlation

, 2017
Shinya Tajima, Keiko Kishimoto, Yoshihide Kanemaki, Ichiro Maeda, Akira Endo, Motohiro Chosokabe, Takafumi Ono, Koichiro Tsugawa, Masayuki Takagi   +8 more
openalex   +2 more sources

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Cell-free RNA profiling uncovers non-canonical circulating D2 transcript elevation in Bladder Cancer plasma. [PDF]

J Liq Biopsy
Nappi A, Crocetto F, Conforti P, Sagliocchi S, Cicatiello AG, Restolfer F, Acampora L, Del Mastro S, Sirica R, Spirito L, Del Giudice F, La Rocca R, Terracciano D, Dentice M, Miro C.   +14 more
europepmc   +1 more source

Pathological tau signatures and nuclear alterations in neurons, astrocytes and microglia in Alzheimer's disease, progressive supranuclear palsy, and dementia with Lewy bodies

, 2022
Mauro Montalbano, Lajja Majmundar, Urmi Sengupta, Leiana Fung, Rakez Kayed   +4 more
openalex   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

SS-HPT nanocarrier delivery of Hif-1α-shRNA reduces pathological lactylation and alleviates inflammation in a sustained hypoxia mouse model

Yubing Zeng, Yongxiang Wei, Chen Chen, Jinying Shen, Jin Qian, Xiaolin Ma, Mengrui Su, Ting Zhang, Bingran Yu, Chunmei Zhu, Shan Wang   +10 more
openalex   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Photodynamic therapy for recurrent spinal diffuse midline glioma with a modest extension of overall survival: illustrative case. [PDF]

J Neurosurg Case Lessons
Fukumura M, Tani M, Kazuki R, Kashiwagi H, Kosaka T, Kawabata S, Nonoguchi N, Endo T, Takami T, Wanibuchi M.   +9 more
europepmc   +1 more source