Results 201 to 210 of about 2,802,342 (335)

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Predictors of lateral lymph node metastasis and prognostic factors in patients with low rectal cancer who underwent lateral lymph node dissection without preoperative treatment. [PDF]

Ann Coloproctol
Ohno R, Oi H, Natsume S, Kawasaki K, Yoshioka Y, Kakizawa N, Kishikawa J, Nagasaki T.   +7 more
europepmc   +1 more source

Assessment of Pathologic Response in Patients With Locally Advanced Rectal Cancer: Implications of the Park et al. Study

, 2013
Annie R. Truong, Steven H. Wei
openalex   +2 more sources

Systems pathology [PDF]

Breast Cancer Research, 2010
openaire   +3 more sources

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

EP-1275: Patients with locally advanced rectal cancer (larc): predictive factors of pathological response

, 2017
S. Montrone, A. Sainato, Riccardo Morganti, Caterina Vivaldi, B. Manfredi, Concetta Laliscia, M. Cantarella, Gabriele Coraggio, Gianna Musettini, Alessandra Gonnelli, Gianni Masi, P Buccianti, F. Pasqualetti, Fabiola Paiar   +13 more
openalex   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Association of P-Wave Parameters With Left Atrial Hemodynamics in Atrial Cardiomyopathy. [PDF]

Ann Noninvasive Electrocardiol
Kazantzi M, Mohr A, Schneider R, Labedi A, Bach N, Rößler J, Salmen S, Gold R, Haghikia A, Kreimer F, Gotzmann M.   +10 more
europepmc   +1 more source

Calcium‐sensing receptor induces the apoptosis of chondrocytes in cooperation with phosphate transporter

FEBS Open Bio, EarlyView.
Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani, Hiroya Ueda, Ayumi Kawata, Yuki Sato, Kotomi Inomata, Hiroshi Mano, Masahiro Wada, Kenji Kobata   +7 more
wiley   +1 more source

Tumor distribution type helps distinguish the prognosis of HCC patients with multiple tumors in BCLC-A stage: a multi-center retrospective study. [PDF]

Ther Adv Med Oncol
Ding W, Tian X, Yang Y, Xu H, Li X, Yu J, Liang P.   +6 more
europepmc   +1 more source